氢吗啡酮复合罗哌卡因用于小儿术后镇痛的有效性和安全性  

Effectiveness and safety of hydromorphone combined with ropivacaine for postoperative analgesia in children

作　　者：陈三冬 魏峥 王帅[1] CHEN San-dong;WEI Zheng;WANG Shuai(Children's Hospital Affiliated of Zhengzhou University,Henan Children's Hospital,Department of Anesthesiology,Zhengzhou Children's Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州大学附属儿童医院,河南省儿童医院,郑州儿童医院麻醉科,郑州450000

出　　处：《医药论坛杂志》2024年第10期1087-1090,共4页Journal of Medical Forum

摘　　要：目的探讨氢吗啡酮复合罗哌卡因对小儿术后镇痛的效果,及对患儿安全性的影响。方法选取2020年8月至2022年8月在郑州大学附属儿童医院接受治疗的手术患儿80例,随机分为复合组、对照组,每组40例。气管插管完成后,对照组采用骶管内注射0.20%罗哌卡因0.2 mg/kg,复合组采用骶管内注射氢吗啡酮0.2 mg/kg+罗哌卡因0.2 mg/kg。比较两组患儿FLACC镇痛评分、Ramsay镇静评分及不良反应发生情况。结果比较两组患儿术后FLACC镇痛评分,复合组4、8、12 h FLACC评分均较对照组更低(P<0.05);比较两组患儿术后Ramsay镇静评分,4、8、12 h的Ramsay评分复合组高于对照组(P<0.05);比较两组患儿术后不良反应发生率,无显著差异(P>0.05)。结论小儿术后镇痛采用骶管内注入氢吗啡酮复合罗哌卡因,镇痛效果较为理想,镇痛时间有效延长,术后并发症较少,临床应用价值较高。Objective To explore the analgesic effect of hydromorphone combined with ropivacaine on postoperative pain in children and its impact on the safety of children.Methods Totally eighty surgical children who received treatment in Children's Hospital Affiliated of Zhengzhou University from August 2020 to August 2022 were collected as the study subjects and randomly grouped into a composite group and a control group,with 40 cases in each group.After tracheal intubation,the control group received intrasacral injection of 0.20%ropivacaine 0.2 mg/kg,while the composite group received intrasacral injection of hydromorphone 0.2 mg/kg+ropivacaine 0.2 mg/kg.The FLACC pain relief score,Ramsay sedation score,and incidence of adverse reactions were compared between the two groups.Results Comparing the postoperative FLACC pain relief scores of the two groups,the composite group had lower FLACC scores at 4,8,and 12 hours compared to the control group(P<0.05);Comparing the postoperative Ramsay sedation scores of two groups,the Ramsay sedation scores of the composite group were higher than those of the control group at 4,8,and 12 hours(P<0.05);There was no significant difference in the incidence of postoperative adverse reactions between the two groups(P>0.05).Conclusion The injection of hydromorphone combined with ropivacaine into the sacral canal for postoperative analgesia in children has an ideal analgesic effect.It can effectively prolong the analgesic time,reduce postoperative complications,and has high clinical application value.

关 键 词：小儿 氢吗啡酮 罗哌卡因 术后镇痛 安全性 

分 类 号：R726.1[医药卫生—儿科]