大青龙汤辅助治疗小儿哮喘有效性和安全性的meta分析  

Meta Analysis of Efficacy and Safety of Daqinglong Decoction in Adjuvant Treatment of Children with Asthma

作　　者：张梅[1] 徐寅鹏 田怿淼 黄鹂[1] ZHANG Mei;XU Yinpeng;TIAN Yimiao;HUANG Li(Pharmacy Department,Zhengzhou Maternal and Child Health Care Hospital,Zhengzhou 450000,China;Pharmacy Department,the Ninth People’s Hospital of Zhengzhou,Zhengzhou 450000,China)

机构地区：[1]郑州市妇幼保健院药学部,河南郑州450000 [2]郑州市第九人民医院药学部,河南郑州450000

出　　处：《河南医学研究》2024年第12期2135-2140,共6页Henan Medical Research

摘　　要：目的 对大青龙汤辅助治疗小儿哮喘的临床安全性和有效性进行系统评价。方法 使用计算机检索万方数据库、中国知网数据库、中国生物医学数据库、维普数据库、Cochrane Library、PubMed,录入大青龙汤辅助治疗哮喘患儿的临床对照试验,由两名独立评价员分别选择试验并且评价质量,提取有效数据后采用RevMan 5.3.3版本软件进行meta分析。结果 共纳入19个临床对照试验研究,收集到病例1 472例,meta分析结果表明,单纯常规治疗组与大青龙汤辅助治疗组的总有效率、第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、FEV_(1)/FVC、哮鸣音证候积分比较,差异有统计学意义(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论 大青龙汤对小儿哮喘的治疗效果明显,虽然药品不良反应轻微,安全系数较高,但还需更多高质量、严谨、多中心的大样本临床对照试验加以验证。Objective To systematically evaluate the clinical safety and effectiveness of Daqinglong decoction in the adjuvant treatment of asthma in pediatric patients.Methods A computer search was performed on Wanfang database,CNKI database,CBM database,VIP database,Cochrane Library and PubMed,and controlled trials designed for Daqinglong decoction on children with asthma were randomized.Two independent evaluators selected the trials and evaluated the quality respectively.After extracting valid data,meta-analysis was performed using RevMan 5.3.3 software.Results A total of 19 controlled clinical trials were included,and 1472 cases were collected.The meta-analysis results showed that there was a statistically difference in the total effective rate,forced expiratory volume at 1 second(FEV_(1)),forced vital capacity(FVC),FEV_(1)/FVC and wheezing syndrome score between the simple conventional treatment group and the Daqinglong decoction adjuvant treatment group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Daqinglong decoction has obvious therapeutic effect on asthma children,although the adverse drug reaction is slight and the safety factor is high,but more high-quality,rigorous,multicentre,large sample controlled trial is needed to verify it.

关 键 词：大青龙汤 小儿哮喘 META分析 

分 类 号：R974[医药卫生—药品]