NLR、PLR与血脂正常的老年2型糖尿病患者颈动脉粥样硬化的关系  

Relationship Between NLR, PLR and Carotid Atherosclerosis inElderly Patients with Type 2 Diabetes with Normal Lipids

作　　者：卢珊珊 陈玉娟[1] 乔磊 杨再刚[1] LU Shanshan;CHEN Yujuan;QIAO Lei;YANG Zaigang(Geriatric Endocrinology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院老年内分泌,河南郑州450000

出　　处：《河南医学研究》2024年第12期2169-2173,共5页Henan Medical Research

基　　金：河南省高等学校重点科研项目(212102310773)。

摘　　要：目的 探讨血脂正常的老年2型糖尿病(T2DM)患者中性粒/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)与颈动脉粥样硬化的关系。方法 选取郑州大学第一附属医院2022年1月至2023年7月收治的246例血脂水平正常的T2DM患者,对患者进行颈动脉超声检查并记录其动脉粥样硬化情况,根据有无动脉粥样硬化将患者分为单纯T2DM组(C-IMT<1 mm,即A组)120例及T2DM合并颈动脉粥样硬化组126例(C-IMT≥1 mm,即B组),检测并比较两组患者NLR、PLR、血小板、中性粒细胞、淋巴细胞等,运用多因素logistic模型探究影响T2DM患者颈动脉粥样硬化的危险因素。通过受试者工作特征(ROC)曲线评估NLR、PLR诊断T2DM患者颈动脉粥样硬化的价值。结果 与A组相比,B组NLR、PLR、血小板、中性粒细胞、白细胞水平均增高,差异有统计学意义(P<0.01)。多因素logistic模型结果显示,NLR、PLR是T2DM患者合并颈动脉粥样硬化的危险因素。ROC曲线分析显示,NLR、PLR单项或联合检测对老年T2DM患者颈动脉粥样硬化均具有较高的诊断价值(P<0.01),当NLR与PLR联合检测时曲线下面积(AUC)、特异度最高。结论 NLR、PLR是老年T2DM患者合并颈动脉粥样硬化的独立危险因素,对于是否发生颈动脉粥样硬化病变的具有诊断价值。Objective To investigate the relationship between neutrophil/lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR)and carotid atherosclerosis in elderly patients with type 2 diabetes mellitus(T2DM)with normal blood lipids.Methods A total of 246 patients with T2DM with normal blood lipid levels were selected from the First Affiliated Hospital of Zhengzhou University from January 2022 to July 2023.According to the presence or lack of atherosclerosis,the patients were divided into T2DM group(C-IMT<1 mm,group A)with 120 cases and T2DM combined with carotid atherosclerosis group(C-IMT≥1 mm,group B)with 126 cases.NLR,PLR,platelets,neutrophils,and lymphocytes were detected and compared between the two groups.The risk factors of carotid atherosclerosis in T2DM patients were investigated by using multivariate logistic model.The diagnostic value of NLR and PLR for carotid atherosclerosis in T2DM patients was reflected by receiver operating characteristic(ROC)curve.Results Compared with group A,the levels of NLR,PLR,platelets,neutrophils and leukocytes in group B were increased,and the differences were statistically significant(P<0.01).The conclusion of multivariate logistic model showed that NLR and PLR were risk factors for carotid atherosclerosis in patients with T2DM.ROC curve analysis showed that NLR and PLR single or combined detection had high diagnostic value for carotid atherosclerosis in elderly patients with T2DM(P<0.01),and the area under the curve(AUC)value and specificity were the highest when NLR and PLR were combined detection.Conclusion NLR and PLR are independent risk factors for carotid atherosclerosis in elderly patients with T2DM,and have diagnostic value for the occurrence of carotid atherosclerosis.

关 键 词：2型糖尿病 中性粒/淋巴细胞比值 血脂 颈动脉粥样硬化 老年 

分 类 号：R587.1[医药卫生—内分泌]