Prevalence and serotype distribution of nasopharyngeal carriage of Streptococcus pneumoniae among healthy children under 5 years of age in Hainan Province, China  

作　　者：Jian Wang Li Qiu Shuang Bai Wei Zhao Ao Zhang Jing Li Jun-Nan Zhang Shan-Shan Zhou Ren Qiu Zhu Huang Jv-Xia Liu Ting-Bin Wang Xue Sun Jiang Wu Qun Zheng Bin He Min Lv 

机构地区：[1]Beijing Center for Disease Prevention and Control,Beijing,China [2]Beijing Research Center for Respiratory Infectious Diseases,Beijing,China [3]Hainan Provincial Center for Disease Control and Prevention,Haikou,China [4]Haikou Center for Disease Control and Prevention,Haikou,Hainan,China [5]Wanning Center for Disease Control and Prevention,Wanning,Hainan,China [6]Baisha County Center for Disease Control and Prevention,Baisha,Hainan,China [7]Qiongzhong County Center for Disease Control and Prevention,Qiongzhong,Hainan,China

出　　处：《Infectious Diseases of Poverty》2024年第1期42-52,共11页贫困所致传染病（英文）

基　　金：This research was funded by Bill&Melinda Gates Foundation(No.INV-034554);Beijing Municipal Natural Science Foundation(No.L202007);Special funds for the construction of high-level public health technical personnel from Beijing Municipal Health Commission(No.2022-3-01-021).

摘　　要：Background The thirteen-valent pneumococcal conjugate vaccine(PCV13)is not included in the national immu-nization program and is administered voluntarily with informed consent in China.In preparation for assessing the impact of pilot introduction in Hainan Province,we conducted a carriage study among children under 5 years of age from four locations in Hainan Province,China.Methods From March to June 2022,nasopharyngeal(NP)swabs,collected from healthy children aged younger than 59 months who lived in the 4 different locations(Haikou,Wanning,Baisha and Qiongzhong)in Hainan Province,were tested for pneumococcus using conventional culture.Pneumococcal isolates were serotyped using the Quel-lung reaction.Risk factors associated with pneumococcal colonization were assessed using univariate analysis and multivariable logistic regression adjusting for age,daycare attendance and other factors.Results Pneumococcus was isolated in 710(30.4%)of the 2333 children enrolled.Of 737 pneumococci,29 serotypes were identifed;60.9%were PCV13 serotypes;the most common vaccine serotypes were 6B(20.4%),19F(13.0%),6A(11.9%)and 23F(6.1%);and the most common nonvaccine serotypes were 23A(12.9%),34(6.1%)and nontypeable(NT)pneumococci(5.6%).Children vaccinated with PCV13 had lower carriage(17.7%vs 32.5%;P=0.0001)and fewer PCV13 serotypes(41.9%vs 62.7%;P=0.0017)compared to unimmunized children.After adjustment,NP carriage Was higher among children attending daycare(aOR=2.3,95%CI:1.7-3.2),living in rural areas(aOR=1.4,95%CI:1.1-1.8),living with siblings(aOR=1.3,95%CI:1.0-1.6)and whose mothers had completed senior high/technical sec-ondary school(aOR=1.5,95%CI:1.1-2.0).In contrast,completion of 3-4 doses of PCV13 were associated with a lower carriage rate(aOR=0.6,95%CI:0.4-0.9).Conclusions We established the baseline of pneumococcal carriage,serotype distribution and PCV13 immuni-zation rates among healthy children under 5 years of age in Hainan Province,prior to the introduction of PCV13 into the national immunization program.The high proport

关 键 词：PNEUMOCOCCUS Nasopharyngeal carriage Serotypes distribution CHILDREN Hainan Province China 

分 类 号：R725.1[医药卫生—儿科]