丙戊酸调节一氧化氮合成的研究进展  

Progress on regulation of nitric oxide synthesis by valproic acid

作　　者：陆燕琴 向往 容德昌 王军[1] LU Yanqin;XIANG Wang;RONG Dechang;WANG Jun(Industrial Fermentation Collaborative Innovation Center Biomedical and Molecular Diagnostics Team,Hubei University of Technology,Wuhan 430068;Autistic Depression Diagnostic and Intervention Institute,Hubei University of Technology,Wuhan 430068;Hubei University of Technology,Cell Regulation and Molecular Drug"111"Introduction Center,Wuhan 430068,China)

机构地区：[1]湖北工业大学工业发酵协同创新中心,湖北武汉430068 [2]湖北工业大学孤独症抑郁症诊断与干预研究所,湖北武汉430068 [3]湖北工业大学细胞调控与分子药物“111”引智基地,湖北武汉430068

出　　处：《生物技术》2024年第2期261-268,共8页Biotechnology

基　　金：科技部高端外国专家项目(G2022027010L);湖北省教育厅创新团队项目(T2020009);湖北省高端人才项目(337/370)。

摘　　要：丙戊酸(valproic acid, VPA)是一种可透过血脑屏障的短链脂肪酸,具有致畸、神经发育障碍乃至死亡的风险,也具有保护心脑血管、抗癫痫、减轻肾损伤、抑菌、促进神经细胞分化等作用,这些对机体的保护作用与一氧化氮(nitric oxide, NO)的合成密切相关。NO是人体内维持正常生理功能所必需的自由基小分子,NO失衡会改变细胞功能,引起人体病理性疾病。VPA通过抑制NO合成来增强致畸性,促进NO合成增强血管保护作用、抗癫痫、抑菌性、诱导细胞分化作用以及减轻NO缺乏所致的肾损伤。该文首次介绍了VPA通过调节NO的合成来对机体产生上述作用,归纳了VPA调节NO的途径及其相对应产生的影响。Valproic acid(VPA)is a kind of short-chain fatty acid that can pass through the blood-brain barrier,which has the risk of teratogen,neurodevelopmental disorders and even death.It also has the functions of protecting cardiovascular and ce-rebrovascular,anti-epilepsy,reducing kidney damage,inhibiting bacteria and promoting nerve cell differentiation.These pro-tective effects are closely related to the synthesis of nitric oxide(NO).NO is a small molecule of free radicals necessary to maintain normal physiological functions in the human body.The imbalance of NO will change cell function and cause pathologi-cal diseases in the human body.VPA enhances teratogenicity by inhibiting NO synthesis,promoting NO synthesis to enhance vascular protection,antiepileptic,bacteriostatic,inducing cell differentiation,and alleviating kidney injury caused by NO defi-ciency.This review introduces for the first time the above-mentioned effects of VPA on the body by regulating NO synthesis,and summarizes the pathway of VPA regulating NO and its corresponding effects.

关 键 词：丙戊酸 一氧化氮 合成 致畸性 心脑血管 癫痫 肾损伤 抑菌 神经细胞 

分 类 号：R971.6[医药卫生—药品]