Superior effectiveness and acceptability of saliva samples for the detection of SARS-CoV-2 in China  

作　　者：Hui Yao Ying Shen Zhichao Liang Xiaoyu Xue Chenxi Zhao Xiang Xu Yuxin Cai Yonghong Liu Wei Zhang Yang Pan Xiaoli Wang 

机构地区：[1]Beijing Office of Global Health,Beijing Center for Disease Prevention and Control,Beijing 100013,China [2]Institute for Infectious Disease and Endemic Disease Control,Beijing Center for Disease Prevention and Control,Beijing 100013,China [3]National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China [4]Center for Drug Evaluation,National Medical Products Administration,Beijing 100176,China [5]School of Public Health,Capital Medical University,Beijing 100069,China

出　　处：《Biosafety and Health》2024年第2期88-91,共4页生物安全与健康（英文）

基　　金：supported by Science Program of Beijing City[grant number Z221100007922019];the High Level Public Health Technical Talent Training Plan[grant number xuekegugan-01-019];National Key Research and Development Project of China[grant number 2023YFC0872400]。

摘　　要：In response to problems of poor sampling quality,low sensitivity,and high demand for medical personnel regarding the current severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)oropharyngeal(OP)swab sampling used in China,we aimed to evaluate the diagnostic performance and acceptability of saliva-based nucleic acid amplification tests(NAATs)in China.The results showed that,using nasopharyngeal(NP)swab results as the gold standard,the overall sensitivities for saliva specimens and OP swabs were 93.3%and 85.0%,the specificities were 92.6%and 93.8%,respectively.The results of an acceptability survey showed that the scores for saliva,OP,and NP samples were 9.46±1.69,8.11±2.42,and 4.58±3.82 out of 10,respectively,with significant differences among the three groups(P<0.05).With higher sensitivity,comparable specificity,and strong public preference,saliva-based NAATs represent a convenient and effective method for detecting SARS-CoV-2 in future epidemics.

关 键 词：SARS-CoV-2 Saliva sample Sensitivity ACCEPTABILITY 

分 类 号：R511[医药卫生—内科学]