观察盐酸左西替利嗪口服溶液联合丙酸氟替卡松气雾剂治疗过敏性鼻炎合并支气管哮喘患儿的临床疗效  

Observation of the Clinical Efficacy of Levocetirizine Hydrochloride Oral Solution Combined with Fluticasone Propionate Aerosol in the Treatment of Children with Allergic Rhinitis and Bronchial Asthma

作　　者：蒿书梅 Hao Shumei(Yanzhou District People’s Hospital,Jining City,Shandong Province,272100,China)

机构地区：[1]济宁市兖州区人民医院,山东济宁272100

出　　处：《中国医学文摘（耳鼻咽喉科学）》2024年第3期40-42,共3页Chinese Medical Digest(Otorhinolaryngology)

摘　　要：目的评价过敏性鼻炎合并支气管哮喘患儿治疗中选用盐酸左西替利嗪口服溶液联合丙酸氟替卡松气雾剂的临床疗效。方法研究区间为2022年5月~2023年11月,研究对象取自我院就治的过敏性鼻炎合并支气管哮喘患儿,筛选出病例数80例按照随机双盲法为原则分组,对照组接受丙酸氟替卡松气雾剂,观察组在此治疗基础上联合盐酸左西替利嗪口服溶液,对比两组患儿的治疗效果、肺功能指标和血清学水平。结果观察组用药治疗的总有效率为97.50%,明显比对照组的82.50%高;相较于对照组,观察组患儿治疗后的各项肺功能指标测定值显著更高,差异有统计意义(P<0.05);治疗前的血清学指标差异无意义,治疗后观察组患儿的肿瘤坏死因子-α和C反应蛋白水平均低于对照组,统计结果P<0.05。结论小儿过敏性鼻炎合并支气管哮喘的治疗选择盐酸左西替利嗪口服溶液+丙酸氟替卡松气雾剂的疗效显著,对改善患儿的肺功能和消除体内炎症的效果突出,值得临床采纳。Objective To evaluate the clinical efficacy of levocetirizine hydrochloride oral solution combined with fluticasone propionate aerosol in the treatment of children with allergic rhinitis complicated with bronchial asthma.Method The study period is from May 2022 to November 2023.The study subjects were selected from children with allergic rhinitis and bronchial asthma who were treated in their own hospital.A total of 80 cases were selected and randomly divided into two groups based on a double-blind method.The control group received fluticasone propionate aerosol,while the observation group received levocetirizine hydrochloride oral solution on the basis of this treatment.The treatment effect,lung function indicators,and serum levels of the two groups of children were compared.Result The total effective rate of medication treatment in the observation group was 97.50%,significantly higher than the 82.50%in the control group;Compared with the control group,the observation group had significantly higher values of various lung function indicators after treatment,and the difference was statistically significant(P<0.05);There was no significant difference in serum indicators before treatment,and tumor necrosis factor was observed in the observation group of children after treatment-αThe levels of C-reactive protein and C-reactive protein were lower than those of the control group,with a statistical result of P<0.05.Conclusion The treatment of pediatric allergic rhinitis combined with bronchial asthma using oral solution of levocetirizine hydrochloride and fluticasone propionate aerosol has a significant therapeutic effect on improving lung function and eliminating inflammation in the body.It is worthy of clinical adoption.

关 键 词：过敏性鼻炎 支气管哮喘患儿 盐酸左西替利嗪口服溶液 丙酸氟替卡松气雾剂 临床疗效 

分 类 号：R72[医药卫生—儿科]