病毒感染诱导血小板减少发病机制的研究进展  

Research progress on the pathogenesis of viral infection induced thrombocytopenia

作　　者：佀瑶瑶 郑文君 全传松 张红 SI Yaoyao;ZHENG Wenjun;QUAN Chuansong;ZHANG Hong(Department of Hematopatholog,the Second Affiliated Hospital of Shandong First Medical University,Tai'an 271000,China;School of Basic Medical Sciences,Shandong First Medical University,Jinan 250117,China)

机构地区：[1]山东第一医科大学第二附属医院血液内科,泰安271000 [2]山东第一医科大学(山东省医学科学院)临床与基础医学院,济南250117

出　　处：《国际免疫学杂志》2024年第3期312-317,共6页International Journal of Immunology

基　　金：山东省医药卫生科技发展计划项目(202011001103);泰安市科技创新发展项目(2021NS220)。

摘　　要：血小板减少是病毒感染性疾病的一种常见临床表现,病毒感染人体后,能够通过抑制血小板生成、增加血小板损耗、免疫损伤及促进血小板破坏等途径共同导致血小板减少。病毒感染诱导血小板减少的机制可能有骨髓抑制、巨核细胞生成缺陷,炎症诱导的凝血及血管内破坏增加导致的血小板损耗等。文章就病毒感染性疾病诱导血小板减少机制的相关研究进行综述。Thrombocytopenia is a common clinical manifestation of viral infectious diseases.After viral infection human body,it can jointly cause thrombocytopenia by inhibiting platelet production,increasing platelet loss,immune injury and promoting platelet destruction.The mechanism of viral infection induced thrombocytopenia may include bone marrow suppression,defective megakaryocytogenesis,inflammation-induced coagulation and intravascular destruction increased resulting platelet depletion,etc.This review summarizes the mechanisms of thrombocytopenia induced by viral infectious diseases.

关 键 词：病毒感染性疾病 血小板破坏 血小板减少 免疫损伤 血管内 巨核细胞生成 骨髓抑制 发病机制 

分 类 号：R558.2[医药卫生—血液循环系统疾病]