生脉饮加味联合西药治疗慢性心力衰竭气阴两虚证临床研究  

Clinical Study on Modified Shengmai Yin Combined with Western Medicine for Chronic Heart Failure with Qi and Yin Deficiency Syndrome

作　　者：叶罗芳 王志锋 YE Luofang;WANG Zhifeng(Tonglu county Hospital of Chinese Medicine,Tonglu Zhejiang 311500,China)

机构地区：[1]桐庐县中医院,浙江桐庐311500

出　　处：《新中医》2024年第10期35-39,共5页New Chinese Medicine

摘　　要：目的:观察生脉饮加味联合西药治疗慢性心力衰竭气阴两虚证的临床疗效。方法:选取76例慢性心力衰竭气阴两虚证患者,按照随机数字表法分为生脉饮组和对照组,每组38例。对照组给予西药治疗,观察组在对照组基础上给予生脉饮加味治疗。2组均治疗4周。比较2组临床疗效、症状评分、心功能指标[左室射血分数(LVEF)、每搏输出量(SV)]、血清N末端B型利钠肽前体(NT-proBNP)水平、6 min步行试验(6MWT)距离及明尼苏达心衰生活质量调查表(MDCAT)评分,记录不良反应。结果:治疗后,生脉饮组总有效率94.74%,高于对照组78.95%,差异有统计学意义(P<0.05)。2组症状、MDCAT评分均较治疗前降低,LVEF、SV均较治疗前升高,血清NT-proBNP水平均较治疗前降低,6MWT距离均较治疗前增加,差异均有统计学意义(P<0.05);生脉饮组症状、MDCAT评分均低于对照组,LVEF、SV均高于对照组,血清NT-proBNP水平低于对照组,6MWT距离大于对照组,差异均有统计学意义(P<0.05)。2组均未发生药物相关不良反应。结论:生脉饮加味联合西药治疗慢性心力衰竭气阴两虚证,可有效改善患者的临床症状,有助于提升其心功能及生活质量。Objective:To observe the clinical effect of modified Shengmai Yin combined with western medicine for chronic heart failure with qi and yin deficiency syndrome.Methods:A total of 76 cases of patients with chronic heart failure with qi and yin deficiency syndrome were selected and divided into the Shengmai Yin group and the control group according to the random number table method,with 38 cases in each group.The control group received western medicine treatment,and the observation group received modified Shengmai Yin based on the treatment of the control group.Both groups were treated for 4 weeks.The clinical effects,symptom scores,heart function indexes[left ventricular ejection fraction(LVEF),and stroke volume(SV)],levels of N-terminal pro b-type natriuretic peptide(NT proBNP)in serum,6-minute walk test(6MWT)distance,and Minnesota Living with Heart Failure Questionnaire(MDCAT)scores were compared between the two groups.The adverse reactions were recorded.Results:After treatment,the total effective rate was 94.74%in the Shengmai Yin group,higher than that of 78.95%in the control group,the difference being significant(P<0.05).The symptom scores and MDCAT scores in the two groups were decreased when compared with those before treatment,LVEF and SV were increased when compared with those before treatment,NT-proBNP levels in serum were decreased when compared with those before treatment,and 6MWT distance were increased when compared with those before treatment,differences being significant(P<0.05).The symptom score and MDCAT score in the Shengmai Yin group were lower than those in the control group,LVEF and SV were higher than those in the control group,the NT-proBNP level in serum was lower than that in the control group,and the 6MWT distance was greater than that in the control group,differences being significant(P<0.05).There was no drug-related adverse reaction in the two groups.Conclusion:Modified Shengmai Yin combined with western medicine for chronic heart failure with qi and yin deficiency syndrome can effecti

关 键 词：慢性心力衰竭 气阴两虚证 生脉饮 心功能 N末端B型利钠肽前体 生活质量 

分 类 号：R541.6[医药卫生—心血管疾病]