消风散联合针刺清血抗敏方治疗慢性荨麻疹临床研究  

Clinical Study on Xiaofeng San Combined with Acupuncture with Qingxue Kangmin Prescription for Chronic Urticaria

作　　者：张志军 ZHANG Zhijun(Chun'an County Traditional Chinese Medicine Hospital,Chun'an Zhejiang 311700,China)

机构地区：[1]淳安县中医院,浙江淳安311700

出　　处：《新中医》2024年第10期47-51,共5页New Chinese Medicine

摘　　要：目的:观察消风散联合针刺清血抗敏方治疗慢性荨麻疹风热证的临床疗效。方法:选取106例慢性荨麻疹风热证患者,采用随机数字表法分为对照组、试验组,每组53例。对照组给予氯雷他定治疗,试验组在对照组基础上给予消风散联合针刺清血抗敏方治疗。2组均治疗2周,随访12周。比较2组临床疗效、风团数量评分、瘙痒程度评分、血清炎症因子[肿瘤坏死因子-α (TNF-α)、白细胞介素-17 (IL-17)、白细胞介素-23 (IL-23)]水平及不良反应发生率。结果:治疗2周后,试验组总有效率96.23%,高于对照组83.02%(P<0.05)。治疗2周后,2组风团数量、瘙痒程度评分均较治疗前降低(P<0.05),试验组风团数量、瘙痒程度评分均低于对照组(P<0.05)。治疗2周后,2组血清TNF-α、IL-17、IL-23水平均较治疗前降低(P<0.05),试验组血清TNF-α、IL-17、IL-23水平均低于对照组(P<0.05)。治疗期间,试验组不良反应发生率13.21%,与对照组9.43%比较,差异无统计学意义(P>0.05)。结论:消风散联合针刺清血抗敏方治疗慢性荨麻疹风热证,可有效改善患者的症状,降低炎症因子水平,安全性良好。Objective:To observe the clinical effect of Xiaofeng San combined with acupuncture with Qingxue Kangmin Prescription for chronic urticaria with wind-heat syndrome.Methods:A total of 106 cases of patients with chronic urticaria with wind-heat syndrome were selected and divided into the control group and the trial group according to random number table method,with 53 cases in each group.The control group was treated with Loratadine,and the trial group was additionally treated with Xiaofeng San combined with acupuncture with Qingxue Kangmin Prescription based on the treatment of the control group.Both groups were treated for 2 weeks and followed up for 12 weeks.The clinical effects,scores of number of wheal and itching severity,levels of serum inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-17(IL-17),and interleukin-23(IL-23)],and the incidence of adverse reactions were compared between the two groups.Results:After 2-week treatment,the total effective rate was 96.23%in the trial group,higher than that of 83.02%in the control group(P<0.05).After 2-week treatment,the scores of number of wheal and itching severity in the two groups were decreased when compared with those before treatment(P<0.05),and the scores of number of wheal and itching severity in the trial group were lower than those in the control group(P<0.05).After 2-week treatment,the levels of serum TNF-α,IL-17,and IL-23 in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of serum TNF-α,IL-17,and IL-23 in the trial group were lower than those in the control group(P<0.05).During the treatment,the incidence of adverse reactions was 13.21%in the trial group and 9.43%in the control group,there being no significance in the difference(P>0.05).Conclusion:Xiaofeng San combined with acupuncture with Qingxue Kangmin Prescription for chronic urticaria with wind-heat syndrome can effectively improve patients'symptom and reduce levels of inflammatory factors with good safety.

关 键 词：慢性荨麻疹 风热证 消风散 针刺 清血抗敏方 炎症因子 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]