乌灵胶囊联合地塞米松鼓室内灌注治疗慢性耳鸣临床研究  

Clinical Study on Wuling Capsules Combined with Dexamethasone Intramural Infusion for Chronic Tinnitus

作　　者：赵佳 李谊 ZHAO Jia;LI Yi(Department of Otolaryngology and Maxillofacial Surgery,Joint Support Force 988 Hospital of PLA,Zhengzhou Henan 450042,China)

机构地区：[1]中国人民解放军联勤保障部队第九八八医院耳鼻喉颌面外科,河南南郑州450042

出　　处：《新中医》2024年第10期102-106,共5页New Chinese Medicine

摘　　要：目的:观察乌灵胶囊联合地塞米松鼓室内灌注治疗慢性耳鸣的临床疗效。方法:依据随机数字表法将160例慢性耳鸣患者分为对照组和观察组各80例。对照组采用地塞米松鼓室内灌注疗法,观察组在对照组基础上联合乌灵胶囊治疗。2组均治疗4周,并随访1个月。比较2组临床疗效和不良反应发生率,以及治疗前后耳鸣评价量表(TEQ)评分、耳鸣残疾评估量表(THI)评分、匹兹堡睡眠质量指数表(PSQI)评分、中医证候评分、γ-氨基丁酸(GABA)水平和5-羟色胺(5-HT)水平。结果:观察组总有效率为85.00%,对照组为68.75%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组TEQ评分较治疗前降低(P<0.05),且观察组TEQ评分低于对照组(P<0.05)。治疗后,2组THI量表中功能性、情感性、严重性评分均较治疗前降低(P<0.05),且观察组上述3项评分均低于对照组(P<0.05)。治疗后,2组血清GABA水平较治疗前升高(P<0.05),5-HT水平较治疗前降低(P<0.05);且观察组GABA水平高于对照组(P<0.05),5-HT水平低于对照组(P<0.05)。治疗后,2组PSQI评分较治疗前降低(P<0.05),且观察组PSQI评分低于对照组(P<0.05)。治疗后,2组中医证候评分较治疗前降低(P<0.05),且观察组中医证候评分低于对照组(P<0.05)。观察组不良反应发生率为7.50%,对照组为18.75%,2组比较,差异有统计学意义(P<0.05)。结论:在地塞米松鼓室内灌注的基础上联合乌灵胶囊治疗慢性耳鸣疗效显著,可缓解临床症状,改善听觉功能,提高睡眠质量,且可减少不良反应的发生。Objective:To observe the clinical effect of the therapy of Wuling Capsules combined with Dexamethasone intramural infusion on chronic tinnitus.Methods:A total of 160 patients with chronic tinnitus were divided into the control group and the observation group according to random number table method,with 80 patients in each group.The control group was treated with Dexamethasone Intramural Infusion,and the observation group was additionally treated with Wuling Capsules based on the treatment of the control group.Both groups were treated for four weeks and followed up for one month.The clinical effects and incidence of adverse reactions,and Tinnitus Evaluation Questionnaire(TEQ),Tinnitus Handicap Inventory(THI),Pittsburgh Sleep Quality Index(PSQI),traditional Chinese medicine(TCM)syndrome scores and levels ofγ-aminobutyric acid(GABA)and 5-hydroxytryptamine(5-HT)were compared before and after treatment in the two groups.Results:The total effective rate was 85.00%in the observation group and 68.75%in the control group,the difference being significant(P<0.05).After treatment,the TEQ scores in both groups were decreased when compared with those before treatment(P<0.05),and the TEQ score in the observation group was lower than that in the control group(P<0.05).After treatment,function,affection and severity scores of THI in the two groups were decreased when compared with those before treatment(P<0.05),and the above three scores in the observation group were lower than those in the control group(P<0.05).After treatment,the serum GABA levels in the two groups were increased when compared with those before treatment(P<0.05),and the 5-HT levels were decreased when compared with those before treatment(P<0.05),and the GABA level in the observation group was higher than that in the control group(P<0.05),and the 5-HT level was lower than that in the control group(P<0.05).After treatment,the PSQI scores in both groups were decreased when compared with those before treatment(P<0.05),and the PSQI score in the observation group was

关 键 词：慢性耳鸣 乌灵胶囊 地塞米松 鼓室内灌注 听觉功能 睡眠质量 γ-氨基丁酸 

分 类 号：R764.45[医药卫生—耳鼻咽喉科]