基于多组学的尘肺病标志物研究进展  

Research progress on pneumoconiosis markers based on multi-omics analysis

作　　者：陈琼 陈卫红[2] 褚敏捷 Chen Qiong;Chen Weihong;Chu Minjie(Department of Epidemiology and Biostatistics,School of Public Health,Nantong University,Nantong 226019,China;Department of Occupational and Environmental Health,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]南通大学公共卫生学院流行病与卫生统计学系,南通226019 [2]华中科技大学同济医学院公共卫生学院劳动卫生与环境卫生学系,武汉430030

出　　处：《中华劳动卫生职业病杂志》2024年第5期384-395,共12页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：国家重点研发计划项目(2022YFC2503202);国家自然科学基金面上项目(82273715)。

摘　　要：尘肺病病因较明确,致病机制尚不完全清楚,尚无有效治愈尘肺病方法。明确尘肺的发病机制并探寻相关标志物,有助粉尘接触高危人群的筛选,相关标志物也可作为干预肺纤维化进程的靶点参考。基因组学、转录组学及蛋白质组学等研究的深入发展为发现更多尘肺病潜在标志物提供了新的途径。未来多组学多阶段交互式分析相结合的技术可系统全面鉴定尘肺病发生发展过程中的关键基因(蛋白)、代谢物及代谢通路,构建核心调控网络,进而筛选出与尘肺病早期诊断及治疗干预相关的敏感标志物。本文从多组学的视角总结尘肺病标志物的研究进展,希望为尘肺病早期预防诊断、发病机制研究以及治疗干预等提供更多基础数据。The etiology of pneumoconiosis is relatively clear,but the pathogenic mechanism is not fully understood,and there is no effective cure for pneumoconiosis.Clarifying the pathogenesis of pneumoconiosis and exploring relevant markers can help screen high-risk groups of dust exposure,and relevant markers can also be used as targets to intervene in the process of pulmonary fibrosis.The in-depth development of genomics,transcriptomics and proteomics has provided a new way to discover more potential markers of pneumoconiosis.In the future,the combination of multi-omics and multi-stage interactive analysis can systematically and comprehensively identify key genes(proteins),metabolites and metabolic pathways in the occurrence and development of pneumoconiosis,build a core regulatory network,and then screen out sensitive markers related to early diagnosis and treatment of pneumoconiosis.This article summarizes the research progress of pneumoconiosis markers from the perspective of multi-omics,hoping to provide more basic data for the early prevention and diagnosis of pneumoconiosis,pathogenesis research,and therapeutic intervention.

关 键 词：尘肺 矽肺 核糖核酸 标志物 基因组学 联系组学 蛋白质组学 代谢组学 单核苷酸多态性 

分 类 号：R135.2[医药卫生—劳动卫生]