抗甲状腺药物所致肝损伤的研究进展  

Research progress on liver injury caused by anti-thyroid drugs

作　　者：黄倩 方坚 阮梅 夏磊 李东良 HUANG Qian;FANG Jian;RUAN Mei;XIA Lei;LI Dongliang(Department of Hepatobiliary Disease,The Third People's Hospital,Fujian University of Traditional Chinese Medicine,Fuzhou 350108,China;Department of Hepatobiliary Disease,The 900th Hospital of the Joint Service Support Force of the People's Liberation Army of China,Fuzhou 350025,China)

机构地区：[1]福建中医药大学附属第三人民医院肝胆科,福建福州350108 [2]联勤保障部队第九〇〇医院肝胆内科,福建福州350025

出　　处：《药物评价研究》2024年第5期927-932,共6页Drug Evaluation Research

基　　金：福建省教育厅中青年教师教育科研项目(JAT210174)。

摘　　要：药物治疗是甲状腺功能亢进的主要治疗方法,常用的抗甲状腺药物包括丙基硫氧嘧啶、甲巯咪唑及其前体药物卡比马唑。这些抗甲状腺药物可引起不同程度的肝损伤。虽然对抗甲状腺药物导致肝毒性的认识已超过70年,但是近年来仍有一些新的报道和阐述。对常见抗甲状腺药物导致肝损伤的发生率、临床病理特点、作用机制以及预防等方面的研究进展进行综述和分析,为临床安全、合理用药提供参考。Pharmacotherapy is the main treatment for hyperthyroidism.The commonly used antithyroid agent include propylthiouracil,methimazole and its precursor,carbimazol.These antithyroid agent can cause varying degrees of liver damage.Although antithyroid agent hepatotoxicity has been recognized for more than 70 years,there are still some new reports and explanations in recent years.This article reviews and analyzes the research progress in the incidence,clinicopathological features,mechanism and prevention of liver injury caused by common antithyroid agent,to provide reference for clinical safety and rational drug use.

关 键 词：甲状腺功能亢进症 抗甲状腺药物 药物性肝损伤 甲巯咪唑 卡比马唑 丙基硫氧嘧啶 

分 类 号：R965.3[医药卫生—药理学]