他汀类药物致药物性肝损伤的研究进展  

Research progress on drug-induced liver injury induced by statins

作　　者：李智 魏栋 万梅绪[3,4] 张燕欣 李智 原景 李德坤[3,4] 高磊 鞠爱春 LI Zhi;WEI Dong;WAN Meixu;ZHANG Yanxin;LI Zhi;YUAN Jing;LI Dekun;GAO Lei;JU Aichun(Inner Mongolia Medical University,Hohhot 010107,China;Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin Tasly Pride Pharmaceutical Co.,Ltd.,Tianjin 300410,China;Tianjin Key Laboratory of Safety Evaluation Enterprise of TCM Injections,Tianjin 300410,China;Inner Mongolia Pharmacovigilance Center,Hohhot 010010,China)

机构地区：[1]内蒙古医科大学,内蒙古呼和浩特010107 [2]天津中医药大学,天津301617 [3]天津天士力之骄药业有限公司,天津300410 [4]天津市中药注射剂安全性评价企业重点实验室,天津300410 [5]内蒙古自治区药物警戒中心,内蒙古呼和浩特010010

出　　处：《药物评价研究》2024年第5期941-950,共10页Drug Evaluation Research

摘　　要：他汀类药物调脂作用显著,是一类较全面的调脂药,能强效降低血清总胆固醇(TC)和低密度脂蛋白(LDL),在心血管疾病预防和治疗中应用广泛。近年来,随着他汀类药物的广泛应用,对其不良反应的研究也日趋深入。肝毒性是此类药物产生的重要不良反应之一,他汀类药物在使用过程中偶有药物性肝损伤(DILI)发生,对他汀类药物致DILI影响因素、相关机制及防治策略的研究进展进行总结,旨在为他汀类药物临床合理使用及DILI的预防提供依据。Statins are a kind of comprehensive lipid-regulating drugs,which can effectively reduce serum total cholesterol(TC)and low density lipoprotein(LDL).Statins are widely used in the prevention and treatment of cardiovascular disease.In recent years,with the wide application of statins,the research on their adverse reactions is becoming increasingly in-depth.Hepatotoxicity is one of the important adverse reactions caused by such drugs.Drug-induced liver injury(DILI)occasionally occurs during the use of statins.This paper summarizes the research progress on the influencing factors,related mechanisms,and prevention and treatment strategies of DILI caused by statins,aiming to provide a basis for rational clinical use of statins and prevention of DILI.

关 键 词：他汀类药物 调脂作用 不良反应 药物性肝损伤 合理用药 

分 类 号：R965.3[医药卫生—药理学]