预知子化学成分、抗消化系统肿瘤药理作用及其药对临床应用研究进展  

Research progress in chemical compounds,pharmacology in anti-digestive system cancers,and herbal pairs of Akebiae Fructus

作　　者：江顺 郭莹莹 赵利军 刘明 邱振鹏 李洪亮 汪选斌 JIANG Shun;GUO Yingying;ZHAO Lijun;LIU Ming;QIU Zhenpeng;LI Hongliang;WANG Xuanbin(Laboratory of Chinese Herbal Pharmacology,Department of Pharmacy,Renmin Hospital,School of Pharmaceutical Sciences,Biomedical Research Institute,Hubei Key Laboratory of Wudang Local Chinese Medicine Research,Hubei University of Medicine,Shiyan 442000,China;School of Pharmacy,Hubei University of Chinese Medicine,Wuhan 430065,China)

机构地区：[1]湖北医药学院附属人民医院药学部中药药理实验室和药学院,武当特色中药研究湖北省重点实验室,湖北医药学院生物医药研究院,湖北十堰442000 [2]湖北中医药大学药学院,湖北武汉430065

出　　处：《药物评价研究》2024年第5期1131-1145,共15页Drug Evaluation Research

基　　金：国家自然科学基金面上项目(82274155);湖北省科技厅对外合作项目(2022EHB046);湖北省自然基金计划(一般面上项目)(2023AFB925);武当特色中药研究湖北省重点实验室开放课题(WDCM2023001;WDCM2023016);“十四五”湖北省高等学校优势特色学科群(现代医学)项目(2022XKQY3)。

摘　　要：预知子(Akebiae Fructus)是武当特色中药,具有抗炎、抗菌、抗肿瘤、抗抑郁等多种药理作用。主要含有三萜皂苷类、绿原酸类等化学成分,在临床使用中多以复方的形式治疗肝癌、胃癌、乳腺癌、前列腺癌等多种肿瘤,尤其是对于消化系统肿瘤,具有很高的使用价值。结合国内外文献对预知子的化学成分、抗消化道肿瘤的药理作用及相关机制、在临床上常用的药对配伍组合进行了归纳总结,以期对明确预知子发挥药理作用的有效成分提供一定参考。对抗消化道肿瘤药理及作用机制的归纳总结,有望对今后预知子抗消化道肿瘤作用机制的深入研究起到一定帮助作用。预知子在临床上常以复方的形式发挥治疗作用,而药对为复方的基本构成单位,对预知子临床上常用药对的归纳总结可为复杂的复方研究提供基础以及对预知子的临床使用提供一定参考。Akebiae Fructus,a Wudang local Chinese medicine,has various pharmacological effects such as anti-inflammatory,antibacterial,anti-cancer,and anti-depression effects.Its compounds include triterpenoid saponins,chlorogenic acid and others.It is clinically used to treat liver cancer,gastric cancer,breast cancer,prostate cancer and other cancers in the forms of formulas,espcially,digestive system cancers.In this study,we reviewed and summarized the chemicals,pharmacology in anti-digestive system cancers,and herbal pairs in clinical compatibility,it is expected to provide some reference for clarifying the active ingredients of Akebiae Fructus that exert pharmacological effects.The summary of anti-digestive system cancers pharmacology and mechanism of action is expected to play a certain role in the further study of anti-digestive system cancers mechanism of Akebiae Fructus in the future.Akebiae Fructus often plays a therapeutic role in the form of compound in clinic,and drug pairs are the basic constituent units of compound.The summary of commonly used drug pairs of Akebiae Fructus in clinic can provide a basis for complex compound research and a certain reference for the clinical use of Akebiae Fructus.

关 键 词：预知子 化学成分 消化系统肿瘤 药对 三萜皂苷 绿原酸 

分 类 号：R285.5[医药卫生—中药学]