二氢槲皮素的药理作用研究进展  

Research progress on pharmacological effects of dihydroquercetin

作　　者：刘欣宇 王艳[1] 陈大忠[1] LIU Xinyu;WANG Yan;CHEN Dazhong(Heilongjiang University of Chinese Medicine,Harbin 150000,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150000

出　　处：《药物评价研究》2024年第5期1153-1159,共7页Drug Evaluation Research

基　　金：黑龙江应用技术研究与开发计划项目(GA19C107)。

摘　　要：二氢槲皮素是从植物中提取的类黄酮类化合物,在自然界中分布广泛,具有抗肿瘤(肝癌、肺癌、乳腺癌、直结肠癌、胃癌、骨癌、宫颈癌)、抗炎、抗氧化、抗纤维化、抗过敏、抗细胞凋亡和抗病毒等多种药理作用。目前对二氢槲皮素在抗氧化、抗炎、抗纤维化和抗细胞凋亡方面的研究比较完善,但缺乏抗病毒和抗肿瘤方面的药理研究总结。就近年来国内外对二氢槲皮素的药理作用(尤其是抗肿瘤活性)的相关文献进行归纳总结,以期为后续研究和进一步药用开发提供依据。Dihydroquercetin is a flavonoid compound extracted from plants and is widely distributed in nature.It has many pharmacological effects such as anti-tumor(such as liver cancer,lung cancer,breast cancer,colorectal cancer,gastric cancer,bone cancer,cervical cancer),anti-inflammatory,antioxidation,antifibrosis,antiallergy,antiapoptosis and antivirus.The existing literature on dihydroquercetin in antioxidation,anti-inflammatory,antifibrosis and antiapoptosis research is relatively perfect;however,there is a lack of summary of research on antivirus and antitumor.In this paper,the pharmacological effects of dihydroquercetin are summarized at home and abroad in recent years,especially its antitumor activity,which provides a theoretical basis for further research and further medicinal development.

关 键 词：二氢槲皮素 抗肿瘤 抗氧化 抗炎 抗纤维化 抗细胞凋亡 

分 类 号：R285.5[医药卫生—中药学]