The dual-action mechanism of Arabidopsis cryptochromes  

作　　者：Gao-Ping Qu Bochen Jiang Chentao Lin 

机构地区：[1]Basic Forestry and Plant Proteomics Research Center,Fujian Agriculture and Forestry University,Fuzhou 350002,China [2]Department of Chemistry,Department of Biochemistry and Molecular Biology,Institute for Biophysical Dynamics,The University of Chicago,Chicago,IL 60637,USA

出　　处：《Journal of Integrative Plant Biology》2024年第5期883-896,共14页植物学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(32330009 and 32000155);China Postdoctoral Science Foundation(2020M670520,2021T140705).

摘　　要：Photoreceptor cryptochromes (CRYs) mediate blue-light regulation of plant growth and development. It has been reported that Arabidopsis CRY1and CRY2 function by physically interacting with at least 84 proteins, including transcription factors or co-factors, chromatin regulators, splicing factors, messenger RNA methyltransferases, DNA repair proteins, E3 ubiquitin ligases, protein kinases and so on. Of these 84 proteins, 47 have been reported to exhibit altered binding affinity to CRYs in response to blue light, and 41 have been shown to exhibit condensation to CRY photobodies. The blue light-regulated composition or condensation of CRY complexes results in changes of gene expression and developmental programs. In this mini-review, we analyzed recent studies of the photoregulatory mechanisms of Arabidopsis CRY complexes and proposed the dual mechanisms of action, including the “Lock-and-Key” and the “Liquid-Liquid Phase Separation (LLPS)” mechanisms. The dual CRY action mechanisms explain, at least partially, the structural diversity of CRY-interacting proteins and the functional diversity of the CRY photoreceptors.

关 键 词：ARABIDOPSIS blue light CRYPTOCHROME CRY1 CRY2 PHASESEPARATION 

分 类 号：Q943.2[生物学—植物学]