利多卡因联用硫化氢供体分子的镇痛作用研究  

Study on the analgesic effect of Lidocaine combined with hydrogen sulfide donor molecule

作　　者：陈春霞 康婷 海澳 柯博文 宋颢[1] CHEN Chunxia;KANG Ting;HAI Ao;KE Bowen;SONG Hao(West China School of Pharmacy,Sichuan University,Chengdu,Sichuan,610041 P.R.China;West China Hospital,West China School of Medicine,Sichuan University,Chengdu,Sichuan,610041 P.R.China)

机构地区：[1]四川大学华西药学院,四川成都610041 [2]四川大学华西临床医学院华西医院,四川成都610041

出　　处：《华西药学杂志》2024年第3期243-246,共4页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目(批准号:82273784);教育部产学合作协同育人项目(202102144022);四川大学研究生教育教学改革研究项目资助(GSSCU2021044)。

摘　　要：目的研究气体信号分子硫化氢对利多卡因镇痛作用的影响。方法以硫氢化钠作为硫化氢供体分子,与利多卡因联用,通过对小鼠的多类型疼痛行为学、足肿胀度、HE染色等进行系统评估,探究硫化氢对利多卡因镇痛作用的影响。结果与利多卡因组比较,利多卡因联用高、中剂量的硫氢化钠(30、15μmol·kg^(-1))对各小鼠疼痛模型均有显著镇痛作用,同时,能显著减轻炎症小鼠后爪的肿胀度和炎症细胞浸润。结论联用硫化氢有助于增强利多卡因的镇痛和抗炎作用。OBJECTIVE To investigate the effect of gas signaling molecule H,S on the analgesic effects of Lidocaine.METHODS Sodium hydrosulfide served as the donor molecule of H,S in conjunction with Lidocaine.The impact of H,S on the analgesic properties of Lidocaine was assessed through a systematic evaluation of various pain-related behaviors,foot swelling degree,and HE staining in mice.RESULTSS Compared to the Lidocaine group,the Lidocaine combined with high and medium doses of sodium hydrosulfide(30μmol·kg^(-1)and 15μmol·kg^(-1))groups demonstrated significant analgesic effects on pain models in mice.Simultaneously,it significantly reduced the degree of swelling and inflammatory cell infiltration of hind paws in mice with inflammation.CONCLUSION The combination of hydrogen sulfide effectively enhances the analgesic and anti-inflammatory effects of Lidocaine.

关 键 词：气体信号分子 硫化氢 供体 利多卡因 镇痛 抗炎 联合用药 

分 类 号：R96[医药卫生—药理学]