十味乳香胶囊对类风湿性关节炎大鼠的治疗作用  

Therapeutic effects of Shiwei Ruxiang capsules on rheumatoid arthritis rats

作　　者：陈海娟 高禹涵[1] 徐丽 张国燕 尚军 CHEN Hajuan;AO Yuhan;XU Li;ZHANG Guoyan;SHANG Jun(Key Laboratory of Medicinal Animal and Plant Resources in Qinghai Tibet Plateau,School of Life Sciences,Qinghai Normal University,Xining,Qinghai,810016 P.R.China;Institute of Plateau Science and Sustainable Development,Qinghai Normal University,Xining,Qinghai,810016 P.R.China)

机构地区：[1]青海师范大学生命科学学院,青海省青藏高原药用动植物资源重点实验室,青海西宁810000 [2]青海师范大学高原科学与可持续发展研究院,青海西宁810000

出　　处：《华西药学杂志》2024年第3期274-278,共5页West China Journal of Pharmaceutical Sciences

基　　金：青海省科技厅应用基础研究项目(2020-ZJ-743);青海省“昆仑英才·高端创新创业人才”项目(2020);青海师范大学博士科研启动经费(2020)。

摘　　要：目的探讨藏药十味乳香胶囊对类风湿性关节炎(RA)大鼠的治疗作用。方法建立胶原诱导的RA大鼠病证结合模型并给予相应药物,观察大鼠的一般状态,测量体重、足跖厚度和踝关节肿胀度。给药28 d后,处死大鼠并收集血液、关节、胸腺和脾组织,用于生化和病理检测。结果十味乳香胶囊可抑制血清和滑膜组织中白细胞介素-6、白细胞介素-1β、肿瘤坏死因子-α的含量,降低CD4^(+)/CD8^(+)T细胞的比例,改善RA大鼠的关节炎症状。结论十味乳香胶囊对RA大鼠具有较好的治疗效果。OBJECTIVE To explore the therapeutic effect of the Tibetan medicine Shiwei Ruxiang capsules on rheumatoid arthritis(RA)rats.METHODS A combination model of collagen-induced RA rats with cold-damp stimulation was established and the rats were given corresponding treatment.The general state of rats was observed daily,and body weight,foot-plantar thickness and ankle joint swelling were measured.28 days after administration,the mice were sacrificed and blood,joint,thymus and spleen tissues were collected for biochemical and pathological tests.RESULTSSShiwei Ruxiang capsules inhibited the levels of IL-6,IL-1β and TNF-α in serum and synovial tissues,decreased the ratio of CD4^(+)/CD8^(+)T cells,and improved the arthritic symptoms of RA rats.CONCLUSION Shiwei Ruxiang capsules demonstrate good therapeutic effect on RA rats.

关 键 词：十味乳香胶囊 类风湿性关节炎 病证结合模型 抗炎 免疫 滑膜 机制 

分 类 号：R96[医药卫生—药理学]