鼻窦炎口服液抑制慢性鼻窦炎远期复发的前瞻性研究  

A prospective study on the long-term therapeutic effect of Sinusitis Oral Solution on recurrence of lesion among patients with chronic sinusitis

作　　者：谢治年 赵元阳 牟思齐 王婷 XIE Zhinian;ZHAO Yuanyang;MU Siqi;WANG Ting(Dept of Otolaryngology,Chongqing Armed Police Corps Hospital,Chongqing,400061,China)

机构地区：[1]武警重庆总队医院耳鼻咽喉科,重庆400061

出　　处：《中国中西医结合耳鼻咽喉科杂志》2024年第3期197-200,208,共5页Chinese Journal of Otorhinolaryngology in Integrative Medicine

摘　　要：目的观察鼻窦炎口服液抑制慢性鼻窦炎远期复发的效果。方法2018年1月~2021年6月于我院治疗的130例慢性鼻窦炎伴鼻息肉患者,按照随机数字表法随机分为观察组和对照组,每组各65例,均实施鼻内镜手术。术后处理中,对照组患者给予生理盐水冲洗鼻腔、糖皮质激素喷鼻,观察组患者则在对照组治疗方法基础上,联用鼻窦炎口服液冲洗鼻腔,疗程均为3月。疗程结束时,比较观察两组患者的临床疗效、症状VAS评分、鼻黏膜纤毛运动功能。然后随访半年,观察比较远期复发率。结果观察组患者总有效率(96.92%)明显高于对照组(84.13%),差异具显著性统计学意义(P<0.05);观察组患者疗后VAS评分显著低于对照组(P<0.05),鼻黏膜纤毛运动功能显著高于对照组(P<0.05),远期复发率(10.77%)明显低于对照组(23.08%),组间差异均具有显著性统计学意义(P<0.05)。结论鼻窦炎口服液对慢性鼻窦炎具有良好的临床疗效,有助于术后鼻黏膜纤毛运动功能恢复,降低远期复发率。Objective To observe the long-term therapeutic effect of Sinusitis Oral Solution(SOS)on recurrence of the lesion among patients with chronic sinusitis.Method Included in this trial were 130 patients suffering from chronic sinusitis with nasal polyps following nasal endoscopic surgery in our hospital from Jan.2018 to Jun.2021.They were randomly divided into observation group(OG)and control group(CG),with 65 cases in each.During the period of postoperative treatment lasted for 3 months,cases in CG were given routine nasal irrigation with normal saline and locally used glucocorticoid nasal spray,while those in OG were treated by nasal irrigation with SOS plus locally used glucocorticoid nasal spray during the whole postoperative treatment period.By the end of postoperative treatment period,comparatively observed were the clinical efficacy,VAS scores of symptoms and nasal mucosal ciliary motility(NMCM).Then,all cases in both groups were followed up for 6 months to observe the long-term therapeutic effect on the condition in a comparative way between the 2 groups.Results The total effective rate in OG was 96.92%,significantly higher than that in CG(84.13%),with significantly statistical significance in the difference(P<0.05).By the end of therapeutic course,VAS scores of patients in OG were significantly lower than that in CG(P<0.05),with NMCM in OG significantly higher than that in CG(P<0.05).When the following up period ended,it was found that the recurrence rate of lesion in OG was 10.77%,significantly lower than that in CG(23.08%),with a markedly statistical significance(P<0.05)between them.Conclusion Sinusitis Oral Solution should be very effective in the treatment of chronic sinusitis,especially helpful to the postoperative recovery via improving nasal mucosal ciliary motor function to reduce the recurrence rate in a longer period.

关 键 词：鼻窦炎 远期复发 鼻窦炎口服液 疗效 

分 类 号：R765.41[医药卫生—耳鼻咽喉科]