腹侧被盖区-内侧前额叶皮质神经环路在觉醒调控过程中作用的研究进展  

Research Progress in the Role of the Ventral Tegmental Area-Medial Prefrontal Cortex Neural Circuit in the Regulation of Arousal

作　　者：郝孟楠 梁小丽 张益 HAO Mengnan;LIANG Xiaoli;ZHANG Yi(Department of Anesthesiology,The Second Affiliated Hospital of Zunyi Medical University,Zunyi,Guizhou 563000,China;Guizhou Key Laboratory of Anesthesia and Organ Protection,Zunyi Medical University,Zunyi,Guizhou 563000,China;School of Anesthesiology,Zunyi Medical University,Zunyi,Guizhou 563000,China)

机构地区：[1]遵义医科大学第二附属医院麻醉科,贵州遵义563000 [2]遵义医科大学贵州省麻醉与器官保护基础研究重点实验室,贵州遵义563000 [3]遵义医科大学麻醉医学院,贵州遵义563000

出　　处：《中国医学科学院学报》2024年第3期402-408,共7页Acta Academiae Medicinae Sinicae

基　　金：贵州省科技厅基础研究项目[黔科合基础-ZK(2023)一般528];贵州省科学技术厅项目[黔科合基础-ZK(2022)一般649];遵义医科大学研究生科研基金立项课题(ZYK252);遵义医科大学临床名医未来人才计划(2021);贵州省高层次创新人才“千层次”人才项目。

摘　　要：腹侧被盖区(VTA)与内侧前额叶皮层(mPFC)之间存在相互神经投射,并形成环路,近年来的研究显示该环路在睡眠与全身麻醉的觉醒调控中发挥着重要的作用。本文通过对VTA与mPFC的解剖结构、二者中的各种神经元及投射通路在觉醒调控过程中的作用进行综述,期望为睡眠觉醒与全身麻醉机制研究提供新的思路。There are mutual neural projections between the ventral tegmental area(VTA)and the medial prefrontal cortex(mPFC),which form a circuit.Recent studies have shown that this circuit is vital in regulating arousal from sleep and general anesthesia.This paper introduces the anatomical structures of VTA and mPFC and the roles of various neurons and projection pathways in the regulation of arousal,aiming to provide new ideas for further research on the mechanism of arousal from sleep and general anesthesia.

关 键 词：中脑腹侧被盖区 内侧前额叶皮层 神经环路 觉醒 

分 类 号：R614[医药卫生—麻醉学]