m^(6)A修饰对药物代谢酶和药物转运体的调控作用  

m^(6)A modification regulates drug-metabolizing enzymes and drug transporters

作　　者：赵世宇 刘帅兵[1] 王月琴[1] 田鑫[1] ZHAO Shi-yu;LIU Shuai-bing;WANG Yue-qin;TIAN Xin(Dept of Pharmacy,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院药学部,河南郑州450052

出　　处：《中国药理学通报》2024年第7期1221-1225,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金面上资助项目(No 32170594);河南省医学科技攻关计划省部共建重大项目(No SBGJ202001007)。

摘　　要：m^(6)A修饰是RNA甲基化修饰中最丰富的一种修饰,受甲基转移酶和去甲基化酶的动态调控,被m^(6)A识别蛋白识别并结合后可影响mRNA的剪切、稳定性和翻译等生物学过程来调控靶基因的表达。最近的研究发现,m^(6)A修饰可通过多种途径来调控药物代谢酶和药物转运体表达,进而影响机体对药物的代谢速率或影响细胞中的药物浓度,最终导致药物治疗效果发生变化。该文综述了m^(6)A修饰调控药物代谢酶和药物转运体分子机制的研究进展,以期为临床上的合理用药、个体化用药提供新思路。N6-methyladenosine(m^(6)A)is the most abundant modification of RNA methylation,dynamically regulated by“writer”and“eraser”,regulating the expression of target genes by modulating key biological processes such as mRNA splicing,stability,and translation,after being recognized and combined by“reader”.Recent studies have revealed that m^(6)A modification can regulate the expression of drug-metabolizing enzymes and transporters,consequently affecting the body′s drug metabolic rate or intracellular drug concentrations,and ultimately influencing therapeutic outcomes.This article reviews the research progress of the molecular mechanism of m^(6)A modification regulating drug-metabolizing enzymes and transporters,so as to provide a new idea for rational and personalized clinicaldrug use.

关 键 词：RNA甲基化 m^(6)A修饰 药物代谢酶 药物转运体 调控机制 研究进展 

分 类 号：R342.2[医药卫生—基础医学] R394.2R969.1R969.3