血管钙化抑制因子BMP-7的研究进展  

Research progresses of endogenous vascular calcification inhibitor BMP-7

作　　者：周鑫 邢露 李鹏权 赵栋 褚海清 贺春霞 秦魏 李慧瑾 付佳 张烨 肖丽 曹慧玲 ZHOU Xin;XING Lu;LI Peng-quan;ZHAO Dong;CHU Hai-qing;HE Chun-xia;QIN Wei;LI Hui-jin;FU Jia;ZHANG Ye;XIAO Li;CAO Hui-ling(Shaanxi Key Laboratory of Ischemic Cardiovascular Disease,Xi’an Key Laboratory of Basic and Translation of Cardiovascular Metabolic Disease,College of Pharmacy,Xi’an Medical University,Xi’an 710021,China)

机构地区：[1]陕西省缺血性心血管疾病重点实验室,西安市心血管代谢疾病基础与转化重点实验室,西安医学院药学院,陕西西安710021

出　　处：《中国药理学通报》2024年第7期1226-1230,共5页Chinese Pharmacological Bulletin

基　　金：陕西省教育厅重点科学研究计划(No 20JS138);国家自然科学基金青年基金项目(No 82200513);陕西省科技厅社发重点项目(No 2022ZDLSF05-15);陕西省科协青年人才托举计划项目(No 20220317);西安医学院博士基金(No 2020DOC28)。

摘　　要：血管钙化是一个主动可调控的心血管系统异位钙化过程,目前尚无可逆转的有效干预手段。血管钙化和骨形成具有共同的调控机制,骨形态发生蛋白7(bone morphogenetic protein 7,BMP-7)可维持血管平滑肌细胞的收缩表型抑制血管钙化。同时,BMP-7可刺激成骨细胞分化过程,增加骨形成,减少骨吸收降低异位钙化压力。该文系统综述BMP-7影响血管钙化的作用与机制及其目前的临床应用现状。这将有助于以BMP-7为新的分子标志物与潜在药物靶标,研发早期诊断试剂盒及治疗药物,以期实现血管钙化的早期预防与干预,改善患者预后。Vascular calcification is a highly regulated process of ectopic calcification in cardiovascular system while no effective intervention can be clinically performed up to date.As vascular calcification undergoes a common regulatory mechanism within bone formation,bone morphogenetic protein 7(BMP-7)maintains contractile phenotype of vascular smooth muscle cells and further inhibits vascular calcification via promoting the process of osteoblast differentiation,reducing ectopic calcification pressure by increasing bone formation and reducing bone resorption.This work systematically reviews the role of BMP-7 in vascular calcification and the possible mechanism,and their current clinical application as well.The current proceedings may help develope early diagnostic strategy and therapeutic treatment with BMP-7 as a new molecular marker and potential drug target.The expectation could achieve early prevention and intervention of vascular calcification and improve poor prognosis on patients.

关 键 词：骨形态发生蛋白7 血管钙化 骨形成 血管平滑肌细胞 分泌蛋白 分子机制 

分 类 号：R322.12[医药卫生—人体解剖和组织胚胎学] R341[医药卫生—基础医学] R541R543R681R692