特异性丁酰胆碱酯酶探针的研究进展  

AN REVIEW IN SPECIFIC BUTYRYLCHOLINESTERASE PROBES

作　　者：孙天雨 任欣予 肖行蒂 汪澜 白笑雪 孙昊鹏[1] SUN Tianyu;REN Xinyu;XIAO Hangdi;WANG Lan;BAI Xiaoxue;SUN Haopeng(School of Pharmacy,China Pharmaceutical University,Nanjing,Jiangsu 211198,China;School of Engineering,China Pharmaceutical University,Nanjing,Jiangsu 211198,China)

机构地区：[1]中国药科大学药学院,江苏南京211198 [2]中国药科大学工学院,江苏南京211198

出　　处：《井冈山大学学报（自然科学版）》2024年第3期35-42,共8页Journal of Jinggangshan University (Natural Science)

基　　金：国家高层次青年人才项目;江苏省自然科学基金面上项目(BK20221522);中国-中东欧国家高校联合教育项目(2022248);江苏省“333高层次人才培养工程”项目。

摘　　要：哺乳动物体内的丁酰胆碱酯酶(butyrylcholinesterase,BChE)能够将学习记忆相关的神经递质乙酰胆碱降解为胆碱和乙酸,以维持胆碱能系统的稳态。由肝脏产生的BChE经血液循环分布于全身多种组织中,具有多种药理相关活性,并且能够作为反映肝脏健康或疾病状况的生物标志物。因此,检测BChE的活性以及了解其在体内的分布和表达情况是开展相关研究基础,本综述简要概述了最近报道的用于定量检测和实时监测BChE的特异性荧光或化学发光探针。Butyrylcholinesterase(BChE)degrades acetylcholine,a neurotransmitter associated with learning and memory,into choline and acetic acid to maintain homeostasia of the cholinergic system in mammals.BChE produced by the liver is distributed in a variety of tissues through the blood circulation,which has extensive pharmacological activities and can be used as a biomarker to reflect the liver health or disease status.Therefore,detecting the activity of BChE and understanding its distribution or expression in vivo is the basis of carrying out relevant researches.Herein,recently reported specific fluorescent or chemiluminescent probes for quantitative detection and real-time monitoring of BChE are briefly summarized.

关 键 词：丁酰胆碱酯酶 荧光探针 化学发光 实时监测 阿尔兹海默症 

分 类 号：Q814.9[生物学—生物工程]