阿托伐他汀治疗2型糖尿病合并颈动脉粥样硬化的效果分析  

Effect Analysis of Atorvastatin in Treatment of Type 2 Diabetes Mellitus with Carotid Atherosclerosis

作　　者：张先智[1] Zhang Xianzhi(Emergency Department,Guizhou Aerospace Hospital,Zunyi 563000,Guizhou Province,China)

机构地区：[1]贵州航天医院急诊科,贵州遵义563000

出　　处：《中国社区医师》2024年第14期28-30,共3页Chinese Community Doctors

摘　　要：目的:分析阿托伐他汀治疗2型糖尿病(T2DM)合并颈动脉粥样硬化的效果。方法:选取2022年1月—2023年1月贵州航天医院收治的T2DM合并颈动脉粥样硬化患者80例作为研究对象,随机分为对照组与干预组,各40例。对照组实施常规治疗,干预组在对照组基础上给予阿托伐他汀治疗。比较两组治疗效果。结果:治疗后,两组空腹血糖、糖化血红蛋白、空腹胰岛素水平低于治疗前,差异有统计学意义(P<0.05)。治疗后,干预组总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平低于治疗前与同期对照组,高密度脂蛋白胆固醇水平高于治疗前与同期对照组,差异有统计学意义(P<0.05)。治疗后,干预组颈动脉内膜中层厚度、斑块厚度、斑块面积小于治疗前与同期对照组,斑块数量少于治疗前与同期对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:阿托伐他汀治疗2型糖尿病合并颈动脉粥样硬化的效果显著,可改善脂代谢指标和颈动脉指标,且用药安全性较高。Objective:To analyze the effect of atorvastatin in treatment of type 2 diabetes mellitus(T2DM)complicated with carotid atherosclerosis.Methods:A total of 80 patients with T2DM complicated with carotid atherosclerosis admitted to Guizhou Aerospace Hospital from January 2022 to January 2023 were selected as the study subjects.They were randomly divided into control group and intervention group,with 40 cases in each group.The control group was given conventional treatment,and the intervention group was treated with atorvastatin on the basis of the control group.The treatment effects were compared between the two groups.Results:After treatment,the fasting blood glucose,glycosylated hemoglobin and fasting insulin levels in the two groups were lower than those before treatment,and the difference was statistically significant(P<0.05).After treatment,the levels of total cholesterol,triglycerides and low density lipoprotein cholesterol in the intervention group were lower than those before treatment and in the control group during the same period,and the levels of high-density lipoprotein cholesterol in the intervention group were higher than those before treatment and in the control group during the same period,and the difference was statistically significant(P<0.05).After treatment,the carotid intima-media thickness,plaque thickness and plaque area in the intervention group were smaller than those before treatment and in the control group during the same period,and the number of plaques in the intervention group was less than that before treatment and in the control group during the same period,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Atorvastatin has a significant effect in the treatment of T2DM complicated with carotid atherosclerosis,and can improve lipid metabolism and carotid artery indexes,and has a high drug safety.

关 键 词：阿托伐他汀 2型糖尿病 颈动脉粥样硬化 

分 类 号：R543.4[医药卫生—心血管疾病]