免疫功能与梅毒血清固定的相关性研究  

Study on the Correlation Between Immune Function and Syphilis Serofast

作　　者：闫薇臣 吴捷 林昌炎 钟娜 YAN Wei-chen;WU Jie;LIN Chang-yan;ZHONG Na(Laboratory Department of Hainan Fifth People's Hospital,Haikou 570102,Hainan,China)

机构地区：[1]海南省第五人民医院检验科,海南海口570102

出　　处：《医学信息》2024年第13期106-109,共4页Journal of Medical Information

基　　金：海南省医药卫生科研项目(编号:21A200303)。

摘　　要：目的了解梅毒血清固定患者免疫功能变化情况,并分析其相关影响因素。方法收集2017年1月-2022年12月在我院就诊的梅毒血清患者临床资料进行回顾性分析,其中发生血清固定者202例设为血清固定组,同期驱梅治疗转阴197例设为治疗有效组。采用多因素Logistic回归方法梅毒血清固定发生的相关因素。结果单因素分析显示,性别、梅毒分期、TRUST初始滴度、IgG和C4是影响梅毒血清固定的危险因素(P<0.05),年龄、IgM、IgA、C3比较,差异无统计学意义(P>0.05)。多因素Logistic分析显示,性别(OR=1.83,95%CI:1.138~2.941,P<0.05)、TRUST初始滴度(OR=1.01,95%CI:1.009~1.022,P<0.05)、IgG(OR=1.07,95%CI:1.019~1.127,P<0.05)和补体C4(OR=0.04,95%CI:0.004~0.465,P<0.05)与梅毒血清固定的发生有关,是梅毒血清固定的独立危险因素。结论机体免疫功能异常状态可能与梅毒血清固定的发生有关。Objective To investigate the changes of immune function in patients with syphilis serofast and analyze the related influencing factors.Methods The clinical data of syphilis patients treated in our hospital from January 2017 to December 2022 were collected and retrospectively analyzed.Of 202 patients with serofast were set as the serofast group,and 197 patients who turned negative after plum blossom expelling treatment were set as the treatment effective group.The related factors of syphilis serofast were analyzed by multivariate logistic regression.Results Univariate analysis showed that gender,syphilis stage,initial titer of TRUST,IgG and C4 were risk factors for syphilis serofast(P<0.05),but there was no significant difference in age,IgM,IgA,C3(P>0.05).Multivariate logistic analysis showed that gender(OR=1.83,95%CI:1.138-2.941,P<0.05),initial titer of TRUST(OR=1.01,95%CI:1.009-1.022,P<0.05),IgG(OR=1.07,95%CI:1.019-1.127,P<0.05)and complement C4(OR=0.04,95%CI:0.004-0.465,P<0.05)were associated with the occurrence of syphilis serofixation,and were independent risk factors for syphilis serofixation.Conclusion The abnormal immune function may be related to the occurrence of syphilis serofast.

关 键 词：免疫功能 梅毒血清固定 影响因素 LOGISTIC分析 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]