前列腺癌根治术患者切除组织中CD4^(+)淋巴细胞水平与盆腔淋巴结转移风险的相关性  

Correlation between tissue cluster of differentiation 4^(+)lymphocytes level and risk of pelvic lymph node metastasis in patients with radical prostate cancer resection

作　　者：迪力夏提·马木提 阿力亚·阿力浦 陈双峰 Dilixiati Mamuti;Aliya Alipu;CHEN Shuangfeng(Department of Urology,Sixth Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,Xinjiang,China;Department of Traditional Chinese Medicine,Sixth Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,Xinjiang,China)

机构地区：[1]新疆医科大学第六附属医院泌尿外科,乌鲁木齐830000 [2]新疆医科大学第六附属医院中医科,乌鲁木齐830000

出　　处：《中国性科学》2024年第6期43-47,共5页Chinese Journal of Human Sexuality

基　　金：新疆维吾尔自治区自然科学基金项目(2018D01C309)。

摘　　要：目的探讨前列腺癌(PC)根治术患者切除组织内CD4^(+)淋巴细胞水平与盆腔淋巴节转移的相关性。方法选取2019年1月至2022年12月新疆医科大学第六附属医院收治的139例首次确诊PC且达到PC根治术实施标准的患者作为研究对象。根据盆腔淋巴结转移情况将所有患者分为未转移组及转移组(发生盆腔淋巴结转移)。统计患者相关资料,并对术中患者切除组织进行流式细胞技术检测,分析影响盆腔淋巴结转移的相关因素。结果未转移组国际泌尿病理学会(ISUP)分级与转移组比较,差异具有统计学意义(P<0.05)。未转移组游离前列腺特异性抗原(PSA)、CD4^(+)Foxp3^(-)PD-1^(-)、CD8^(+)Foxp3^(-)PD-1^(-)、CD8^(+)PD-1^(+)高于转移组,总PSA低于转移组(P<0.05)。游离PSA(OR=0.013)、CD4^(+)Foxp3^(-)PD-1^(-)(OR=0.831)、CD8^(+)Foxp3^(-)PD-1^(-)(OR=0.851)是影响淋巴结转移的独立保护因素(P<0.05)。CD4^(+)Foxp3^(+)PD-1^(-)的曲线下面积(AUC)显著高于CD8^(+)Foxp3^(+)PD-1^(-)及CD8^(+)PD-1^(-)(Z=2.916,3.533;P<0.05)。随着CD4^(+)Foxp3^(+)PD-1^(-)升高,PC患者淋巴结转移的风险呈非线性下降趋势(χ^(2)=0.724,P=0.629)。结论CD4^(+)效应T细胞与PC患者盆腔淋巴结转移存在显著相关性。Objective To investigate the correlation between cluster of differentiation(CD)4^(+)lymphocytes level and pelvic lymph node metastasis in resected tissue from prostate cancer(PC)radical resection.Methods A total of 139 patients admitted to Sixth Affiliated Hospital of Xinjiang Medical University from January 2019 to December 2022 who were diagnosed with PC for the first time and met the implementation criteria for radical PC surgery were selected as study objects.According to the status of pelvic lymph node metastasis,all patients were divided into non-metastatic group and metastatic group(with pelvic lymph node metastasis).The relevant data of the patients were statistically analyzed,and flow cytometry analysis was performed on the resected tissues of the of intraoperative patients.The related factors affecting pelvic lymph node metastasis were analyzed.Results There was a statistically significant difference in international society of urological pathology(ISUP)grading between the non-metastatic group and the metastatic group(P<0.05).Free prostate specific antigen(PSA),CD4^(+)Foxp3^(-)PD-1^(-),CD8^(+)Foxp3^(-)PD-1^(-)and CD8^(+)PD-1^(+)in non-metastatic group were higher than that in metastatic group,and total PSA was lower than that in metastatic group(P<0.05).Free PSA(OR=0.013),CD4^(+)Foxp3^(-)PD-1^(-)(OR=0.831),CD8^(+)Foxp3^(-)PD-1^(-)(OR=0.851)were independent protective factors affecting lymph node metastasis(P<0.05).The area under curve(AUC)of CD4^(+)Foxp3^(+)PD-1^(-)was significantly higher than those of CD8^(+)Foxp3^(+)PD-1^(-)and CD8^(+)PD-1^(-)(Z=2.916,3.533;P<0.05).With the increase of CD4^(+)Foxp3^(+)PD-1^(-),the risk of lymph node metastasis in PC patients showed a non-linear decrease(χ^(2)=0.724,P=0.629).Conclusions CD4^(+)effector T cells were significantly correlated with pelvic lymph node metastasis in PC patients.

关 键 词：前列腺癌 淋巴细胞 淋巴结转移 前列腺癌根治术 

分 类 号：R697[医药卫生—泌尿科学]