麦角新碱联合卡孕栓对剖宫产术后再次妊娠阴道分娩产妇产后出血的影响  

Impact of ergometrine combined with carboprost suppositories on postpartum hemorrhage in pregnant women undergoing vaginal birth after cesarean

作　　者：鲁红艳 王雪影[1] 王小兰[1] LU Hongyan;WANG Xueying;WANG Xiaolan(Department of Perinatal Medicine,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100026,China)

机构地区：[1]首都医科大学附属北京妇产医院围产医学部,北京100026

出　　处：《中国性科学》2024年第6期98-102,共5页Chinese Journal of Human Sexuality

摘　　要：目的探究麦角新碱联合卡孕栓对剖宫产术后再次妊娠阴道分娩(VBAC)产妇产后出血的影响。方法回顾性选取100例于2019年3月至2021年2月在首都医科大学附属北京妇产医院进行VBAC的产妇作为研究对象,根据产妇分娩后接受预防产后出血用药方案的差异分为观察组(n=50)和对照组(n=50)。对照组使用缩宫素联合卡孕栓治疗,观察组在对照组基础上加用麦角新碱治疗。比较两组产妇出血及止血情况、实验室检查结果、临床表现和安全性。结果对照组产妇的产后2 h及产后24 h出血量均大于观察组,对照组产妇的止血时间也长于观察组(P<0.05);治疗后,两组产妇的活化部分凝血活酶时间(APTT)、凝血酶凝固时间(TT)、血红蛋白(Hb)和纤维蛋白原(FIB)均有所降低,且对照组产妇的APTT、TT、FIB均高于观察组,Hb低于观察组(P<0.05);观察组产妇的宫缩持续时间较对照组更长,恶露持续时间和住院时间较对照组显著更短(P<0.05);观察组和对照组产妇的总不良反应发生率分别为14.00%和18.00%,差异无统计学意义(P>0.05)。结论麦角新碱联合卡孕栓能有效改善VBAC产妇产后出血的情况。Objective To investigate the impact of ergometrine combined with carboprost suppositories on postpartum hemorrhage in pregnant women undergoing vaginal birth after cesarean(VBAC).Methods A total of 100 women who underwent VBAC in Beijing Obstetrics and Gynecology Hospital,Capital Medical University from March 2019 to February 2021 were retrospectively selected as study objects and grouped into an observation group(n=50)and a control group(n=50)according to the differences in the drug regimens for the prevention of postpartum hemorrhage after delivery.The control group was treated with oxytocin combined with carboprost suppositories,and the observation group was treated with ergometrine on the basis of the control group.The hemorrhage and hemostasis status,laboratory examination results,clinical manifestations,and safety of postpartum women in the two groups were compared.Results The hemorrhage volume at 2 h and 24 h postpartum in the control group was greater than that in the observation group,and the hemostasis time in the control group was significantly longer than that in the observation group(P<0.05).After treatment,the activated partial thromboplastin time(APTT),thrombin coagulation time(TT),hemoglobin(Hb)and fibrinogen(FIB)of parturients in the two groups were all decreased,and the APTT,TT and FIB of parturients in the control group were all higher than those in the observation group,while the Hb was lower than that in the observation group(P<0.05).The duration of uterine contractions in the observation group was longer than that in the control group,while the duration of lochia and hospital stay were significantly shorter than those in the control group(P<0.05).The total incidence of adverse reactions in the observation group and the control group was 14.00% and 18.00%,respectively,and there was no statistically significant difference between the two groups(P>0.05).Conclusions The combination of ergometrine and carboprost suppository can effectively improve the postpartum hemorrhage of VBAC pregnant women.

关 键 词：麦角新碱 卡孕栓 剖宫产术后再次妊娠阴道分娩 产后出血 

分 类 号：R714[医药卫生—妇产科学]