妊娠期糖尿病患者血清miR-26b、TMAO表达变化及与产后糖代谢异常的相关性  

Changes of serum microRNA-26b and trimethylamine oxide expression in patients with gestational diabetes mellitus and their correlation with postpartum glucose metabolic abnormalities

作　　者：韩慧明 陈绵平 程虹[2] 俞江华 HAN Huiming;CHEN Mianping;CHENG Hong;YU Jianghua(Department of Laboratory,Haikou Maternal and Child Health Hospital,Haikou 570203,Hainan,China;Department of Obstetrics,Haikou Maternal and ChildHealth Hospital,Haikou 570203,Hainan,China;Department of Laboratory,Luliang County TraditionalChinese Medicine Hospital,Qujing 655600,Yunnan,China)

机构地区：[1]海口市妇幼保健院检验科,海口570203 [2]海口市妇幼保健院产科,海口570203 [3]陆良县中医医院检验科,云南曲靖655600

出　　处：《中国性科学》2024年第6期106-110,共5页Chinese Journal of Human Sexuality

基　　金：海南省卫生健康行业科研项目(19A200167)。

摘　　要：目的探讨妊娠期糖尿病(GDM)患者血清微小RNA(miR)-26b、氧化三甲胺(TMAO)表达变化及与产后糖代谢异常间的关系。方法选取海口市妇幼保健院接诊的GDM患者186例作为研究对象。孕24~28周进行口服葡萄糖耐量试验(OGTT),并检测miR-26b、TMAO表达。根据产后6~8周OGTT结果分为异常组(n=52)和正常组(n=134)。Logistic多因素分析miR-26b、TMAO表达与产后糖代谢异常的关系。Pearson相关系数分析24~28周miR-26b、TMAO与产后空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)的相关性。结果调整混杂因素后血清miR-26b、TMAO水平仍与产后糖代谢异常独立相关(P<0.05);异常组产后FPG、FINS、HOMA-IR高于正常组(P<0.05);异常组24~28周miR-26b与产后FPG、FINS、HOMA-IR呈负相关,TMAO与产后FPG、FINS、HOMA-IR呈正相关(P<0.05)。结论GDM患者血清miR-26b、TMAO表达异常,其与产后糖代谢异常关系密切。Objective To investigate the changes of serum microRNA-26b(miR-26b)and trimethylamine oxide(TMAO)expression in patients with gestational diabetes mellitus(GDM)and their correlation with postpartum glucose metabolic abnormalities.Methods A total of 186 patients with GDM admitted to Haikou Maternal and Child Health Hospital were selected as the study objects.Oral glucose tolerance test(OGTT)was performed at 24-28 weeks of pregnancy,and the expressions of miR-26b and TMAO were detected.The patients were divide into abnormal group(n=52)and normal group(n=134)according to the OGTT at 6-8 weeks postpartum.Logistic multivariate analysis was used to analyze the relationship between miR-26b,TMAO expression and postpartum glucose metabolic abnormalities.Pearson correlation coefficient analysis was used to analyze the correlation between miR-26b and TMAO with postpartum fasting plasma glucose(FPG),fasting insulin(FINS)and homeostasis model assessment-insulin resistance(HOMA-IR)at 24-28 weeks.Results After adjusting for confounding factors,serum miR-26b and TMAO levels were still independently correlated with postpartum glucose metabolism abnormalities(P<0.05).Postpartum FPG,FINS and HOMI-IR in abnormal group were higher than those in normal group(P<0.05).MiR-26b was negatively correlated with postpartum FPG,FINS and HOMA-IR in abnormal group at 24-28 weeks,while TMAO was positively correlated with postpartum FPG,FINS and HOMA-IR(P<0.05).Conclusions Serum miR-26b and TMAO of GDM patients express abnormally,and these abnormal conditions are closely related to postpartum glucose metabolic abnormalities.

关 键 词：妊娠期糖尿病 miR-26b TMAO 产后 

分 类 号：R714[医药卫生—妇产科学]