中医三联疗法对脾肾两虚型多囊卵巢综合征不孕症患者卵泡发育、血清INHB水平及妊娠情况的影响  

Impacts of traditional Chinese medicine triple therapy on follicular development,serum inhibin B level,and pregnancy status in patients with polycystic ovary syndrome infertility of deficiency of spleen and kidney type

作　　者：张晓娟 耿静然 贾姗姗 薛淼淼 ZHANG Xiaojuan;GENG Jingran;JIA Shanshan;XUE Miaomiao(Department of Traditional Chinese Medicine,Hebei Maternity Hospital,Shijiazhuang 050000,Hebei,China;Department of Medical,Hebei Maternity Hospital,Shijiazhuang 050000,Hebei,China)

机构地区：[1]河北生殖妇产医院中医科,石家庄050000 [2]河北生殖妇产医院医务科,石家庄050000

出　　处：《中国性科学》2024年第6期139-142,共4页Chinese Journal of Human Sexuality

基　　金：河北省中医药管理局科研项目(2023187,2023186)。

摘　　要：目的探究中医三联疗法对脾肾两虚型多囊卵巢综合征(PCOS)不孕症患者卵泡发育、血清抑制素B(INHB)水平及妊娠情况的影响。方法采用随机数字表法将选取的72例2022年6月至2023年1月于河北生殖妇产医院进行治疗的脾肾两虚型PCOS不孕症患者分为观察组(n=36)和对照组(n=36)。对照组采用克罗米芬进行治疗,观察组在对照组基础上给予中医三联疗法,比较两组患者的卵泡发育情况、激素水平和血清INHB水平、妊娠率。结果两组治疗6个月后的成熟卵泡数均比治疗3个月后有显著提升,且观察组治疗3个月、6个月后的成熟卵泡数均高于对照组(P<0.05);两组治疗3个月、6个月后的黄体生成素(LH)水平均较治疗前有所降低,卵泡刺激素(FSH)和血清INHB水平较治疗前有所提升,且观察组LH水平降低幅度、FSH和血清INHB水平升高幅度均较对照组显著(P<0.05);治疗3个月和6个月后,观察组妊娠率高于对照组,差异具有统计学意义(P<0.05)。结论中医三联疗法能够显著改善脾肾两虚型PCOS不孕症患者的卵泡发育情况,提高其血清INHB水平及妊娠率。Objective To explore the impacts of traditional Chinese medicine triple therapy on follicular development,serum inhibin B(INHB)level,and pregnancy status in patients with polycystic ovary syndrome(PCOS)infertility of deficiency of spleen and kidney type.Methods A total of 72 patients with PCOS infertility of spleen and kidney deficiency type who were treated at Hebei Maternity Hospital from June 2022 to January 2023 were grouped into an observation group(n=36)and a control group(n=36)using random number table method.The control group was treated with clomiphene,and the observation group was given traditional Chinese medicine triple therapy on the basis of the control group.The follicular development level,hormone level,serum INHB level and pregnancy rate of the two groups were compared.Results The numbers of mature follicles in both groups after 6 months of treatment were significantly higher than those after 3 months of treatment,and the numbers of mature follicles in the observation group after 3 months and 6 months of treatment were higher than those in the control group(P<0.05).After 3 months and 6 months of treatment,the levels of luteinizing hormone(LH)decreased compared with that before treatment,and the levels of follicle stimulating hormone(FSH)and serum INHB increased compared with those before treatment.The decrease of LH level and the increases of FSH and serum INHB in the observation group after 3 months and 6 months of treatment were more significant than those in the control group(P<0.05).After 3 and 6 months of treatment,the pregnancy rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusions Traditional Chinese medicine triple therapy can significantly improve the follicular development condition of patients with PCOS infertility of deficiency of spleen and kidney type,and increase their serum INHB level and pregnancy rate.

关 键 词：中医三联疗法 脾肾两虚型多囊卵巢综合征 不孕症 卵泡发育 血清抑制素B 妊娠 

分 类 号：R711[医药卫生—妇产科学]