S100b联合CRP在诊断早产儿脑损伤中的临床价值  

Clinical value of S100b combined with CRP in diagnosis of brain injury in premature infants

作　　者：魏静 刘庆生 闫会丽 韩慧珍 孟伟玲 Wei Jing;Liu Qingsheng;Yan Huili;Han Huizhen;Meng Weiling(Department of Neonatology,Maternal and Child Health Hospital of Jiaozuo City,Jiaozuo,Henan 454001,China)

机构地区：[1]焦作市妇幼保健院新生儿科,河南焦作454001

出　　处：《齐齐哈尔医学院学报》2024年第12期1140-1144,共5页Journal of Qiqihar Medical University

摘　　要：目的探讨S100b联合CRP在诊断早产儿脑损伤(Brain injury in premature infants,BIPI)中的临床效能。方法选择2022年1月—2024年1月于本院儿科确诊的125例BIPI患儿作为BIPI组,另选择同期收治的85例非BIPI早产儿作为对照组。根据BIPI患儿病情严重程度分为轻度BIPI组和重度BIPI组两组亚组。收集所有研究对象的临床资料并检测血清中S100b联合CRP表达水平。Logistic回归分析发生BIPI的危险因素,S100b联合CRP在诊断BIPI的临床效能采用ROC曲线分析。结果对照组、轻度BIPI组和重度BIPI组三组间S100b、CRP表达水平存在统计学差异(P<0.05)。与对照组相比,轻度和重度BIPI组S100b、CRP表达水平均明显升高(P<0.05);与轻度BIPI组相比,重度BIPI组S100b、CRP表达水平均明显升高(P<0.05)。与对照组相比,宫内窘迫、出生后窒息、有创机械通气、新生儿呼吸窘迫综合征发生率及血清中S100b、CRP表达水平在BIPI组中明显升高(P<0.05)。Logistic回归分析结果显示,有创机械通气(OR=1.432)、新生儿呼吸窘迫综合征(OR=2.543)、S100b(OR=3.782)和CRP表达(OR=3.449)是发生BIPI的危险因素。S100b及CRP在诊断BIPI的曲线下面积分别为0.895和0.812,S100b联合CRP在诊断BIPI的曲线下面积为0.931,诊断敏感度和特异度分别为97.43%和92.25%。结论BIPI患儿外周血中S100b和CRP表达水平显著升高,S100b联合CRP在诊断BIPI中具有显著的临床价值。Objective To explore the clinical efficacy of S100b combined with CRP in the diagnosis of brain injury in premature infants(BIPI).Methods A total of 125 infants with BIPI who were diagnosed in pediatric department of our hospital from January 2022 to January 2024 were selected as BIPI group and 85 non-BIPI premature were enrolled in the control group.According to the disease severity of BIPI,all BIPI infants were divided into two subgroups:mild and severe BIPI group.The clinical data and serum expression levels of S100b,CRP of all infants were collected and detected.The Logistic regression analysis was used to identify the risk factors of BIPI,and the clinical efficacy of S100b combined with CRP in the diagnosis of BIPI were analyzed by ROC curve analysis.Results There were significant differences in the serum expression levels of S100b and CRP among the control group,the mild and severe BIPI group(P<0.05).Compared with the control group,the serum expression levels of S100b and CRP in the mild and severe BIPI groups were significantly increased,and the differences were statistically significant(P<0.05).Compared with the mild BIPI group,the serum expression levels of S100b and CRP in the severe BIPI group were significantly increased,and the differences were statistically significant(P<0.05).Compared with the control group,the incidence of intrauterine distress,postnatal asphyxia,invasive mechanical ventilation,neonatal respiratory distress syndrome,and serum expression levels of S100b and CRP were significantly increased in the BIPI group,and the differences were statistically significant(P<0.05).The Logistic regression analysis showed that invasive mechanical ventilation(OR=1.432),neonatal respiratory distress syndrome(OR=2.543),S100b(OR=3.782),and CRP(OR=3.449)were risk factors for the incidence of BIPI.The area under the curve for diagnosing BIPI with S100b and CRP were 0.895 and 0.812,respectively.The area under the curve for diagnosing BIPI with S100b combined with CRP was 0.931,with diagnostic sensitivity a

关 键 词：早产儿脑损伤 危险因素 S100B C反应蛋白 炎症 

分 类 号：R722.6[医药卫生—儿科]