孟德尔随机化分析饮食因素与白内障的因果关系  

Causal relationship between dietary factors and cataract:a Mendelian randomisation analysis

作　　者：范慧敏 柏心如 韩雅婷 朱敏 陶秀彬 Fan Huimin;Bai Xinru;Han Yating;Zhu Min;Tao Xiubin(School of Nursing,Wannan Medical College,Wuhu,Anhui 241000,China;Department of Nursing,the First Affiliated Hospital of Wannan Medical College,Wuhu,Anhui 241000,China)

机构地区：[1]皖南医学院护理学院,安徽芜湖241000 [2]皖南医学院第一附属医院护理部,安徽芜湖241000

出　　处：《齐齐哈尔医学院学报》2024年第12期1192-1196,共5页Journal of Qiqihar Medical University

基　　金：芜湖市“华佗计划”卫生高层次人才项目(芜卫组[2023]111号)。

摘　　要：目的利用孟德尔随机化(MR)分析探究了24种饮食因素与白内障之间的因果关系。方法使用了来自全基因组关联研究(GWAS)的大规模遗传汇总数据,包括24种饮食因素和白内障,运用两样本孟德尔随机化法(Two-Sample Mendelian randomization,TSMR)分析两者之间的因果关联。结果通过MR分析,确定了8种饮食因素与白内障存在因果关系,其中饮用水(OR=0.874;95%CI:0.769~0.994;P=0.040)、凉茶(OR=0.997;95%CI:0.994~1.000;P=0.044)、茶叶中添加糖(OR=0.511;95%CI:0.324~0.805;P=0.004)、谷物(OR=0.797;95%CI:0.636~0.999;P=0.049)、干果(OR=0.722;95%CI:0.566~0.921;P=0.009)以及加工肉类(OR=0.773;95%CI:0.622~0.962;P=0.021)的摄入量增加与降低白内障风险相关。相反,每周摄入强化葡萄酒(OR=3.466;95%CI:1.226~9.802;P=0.019)和速溶咖啡(OR=1.170;95%CI:1.016~1.348;P=0.029)的摄入量与增加白内障风险相关。敏感性分析显示,谷物和干果摄入量相关的SNP存在异质性,强调了对这些因素IVW模型结果的重视。此外,MR-Egger回归未发现SNP之间存在多效性(P>0.05)。共定位分析未发现8种饮食因素与白内障之间共享同一个因果变体的证据。结论使用MR的方法发现8种饮食因素与白内障风险存在因果关系,对护理学具有重要意义,可为护理人员提供指导,帮助他们设计更有效的白内障患者的饮食护理方案,并促进白内障的预防和管理工作。Objective Causal associations between 24 dietary factors and cataract were explored using Mendelian randomisation(MR)analysis.Methods The large-scale genetic pooled data from the Genome-Wide Association Study(GWAS),including 24 dietary factors and cataract,were used to analyse causal associations using two-sample Mendelian randomization(TSMR).Results A causal association between eight dietary factors and cataract was identified by MR analysis,including drinking water(OR=0.874;95%CI:0.769-0.994;P=0.040),herbal tea(OR=0.997;95%CI:0.994~1.000;P=0.044),and added sugar in tea(OR=0.511;95%CI:0.324~0.805;P=0.004),cereals(OR=0.797;95%CI:0.636~0.999;P=0.049),dried fruits(OR=0.722;95%CI:0.566~0.921;P=0.009)and processed meats(OR=0.773;95%CI:0.622-0.962;P=0.021)increased intake was associated with reduced cataract risk.In contrast,weekly intake of fortified wine(OR=3.466;95%CI:1.226~9.802;P=0.019)and instant coffee(OR=1.170;95%CI:1.016~1.348;P=0.029)was associated with an increased risk of cataract.Sensitivity analyses showed heterogeneity in SNPs associated with cereal and dried fruit intake,emphasizing the importance of the IVW model results for these factors.In addition,MR-Egger regression did not find pleiotropy between SNPs(P>0.05).Co-localisation analysis did not find evidence of sharing the same causal variant between the eight dietary factors and cataract.Conclusions The finding of a causal relationship between eight dietary factors and cataract risk using MR in this study has important nursing implications and may provide guidance to caregivers in designing more effective dietary care programs for patients with cataracts,as well as facilitating the prevention and management of cataracts.

关 键 词：饮食 白内障 孟德尔随机化 

分 类 号：R473.77[医药卫生—护理学]