早期炎症和心室重构在急性心肌梗死后作用机制的研究进展  

Research progress on mechanism of early inflammation and ventricular remodeling after acute myocardial infarction

作　　者：王伟潼 陆林肯 卢嘉骏 陈静 孙红 Wang Weitong;Lu Linken;Lu Jiajun;Chen Jing;Sun Hong(Department of Basic Medical Sciences,North China University of Science and Technology,Tangshan 063000,China)

机构地区：[1]华北理工大学基础医学院,河北省慢性疾病重点实验室,唐山063000

出　　处：《国际生物医学工程杂志》2024年第2期188-193,共6页International Journal of Biomedical Engineering

基　　金：国家自然科学基金(U20A20261);河北省自然科学基金(H2023209021);河北省康复工程与再生医学重点实验室(SZX202327)。

摘　　要：急性心肌梗死(AMI)是一种常见且严重的心血管疾病,其发病机制涉及复杂的炎症反应和心肌组织的重构。早期炎症反应在AMI后起关键作用,促进心肌损伤和修复。同时,心室重构作为AMI后的一种生理过程,涉及心肌肥厚、纤维化、扩张和重塑,对心脏功能及预后产生深远影响。因此,深入了解早期炎症和心室重构在AMI后的作用机制具有重要意义。主要对早期炎症和心室重构在AMI后的作用机制进行系统梳理,重点探讨炎症介质在AMI后的动态变化,以及心室重构与预后的相关性,期望为AMI的预防、治疗及预后提供指导和借鉴。Acute myocardial infarction(AMI)is a prevalent and serious cardiovascular disease characterized by a complex inflammatory response and myocardial tissue remodeling.The early inflammatory response plays a key role in the aftermath of AMI,promoting myocardial injury and repair.At the same time,ventricular remodeling,as a physiological process after AMI,involves myocardial hypertrophy,fibrosis,dilation,and remodeling,which has a profound impact on cardiac function and prognosis.Therefore,it is of great significance to understand the mechanism of action of early inflammation and ventricular remodeling after AMI.In this paper,the mechanism of early inflammation and ventricular remodeling after AMI was systematically reviewed,focusing on the dynamic changes of inflammatory mediators after AMI and the correlation between ventricular remodeling and prognosis,hoping to provide guidance and reference for the prevention,treatment,and prognosis of AMI.

关 键 词：急性心肌梗死 早期炎症 心室重构 

分 类 号：R542.22[医药卫生—心血管疾病]