便携呼气振荡驱动的气道阻抗监测系统研究  

Research on portable airway impedance monitoring device based on expiratory oscillation

作　　者：匡英烽 车波 李轩 刘磊 邓林红[2,3] KUANG Yingfeng;CHE Bo;LI Xuan;LIU Lei;DENG Linhong(School of Microelectronics and Control Engineering,Changzhou University,Changzhou,Jiangsu 213164,P.R.China;Institute of Biomedical Engineering and Health Sciences,Changzhou University,Changzhou,Jiangsu 213164,P.R.China;School of Medical and Health Engineering,Changzhou University,Changzhou,Jiangsu 213164,P.R.China)

机构地区：[1]常州大学微电子与控制工程学院,江苏常州213164 [2]常州大学生物医学工程与健康科学研究院,江苏常州213164 [3]常州大学医学与健康工程学院,江苏常州213164

出　　处：《生物医学工程学杂志》2024年第3期430-438,共9页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(12272063);常州市科技支撑计划(CE20215028)。

摘　　要：气道阻抗的监测对肺功能疾病的准确评估及早期诊断具有重要临床价值。针对当前肺功能设备中振荡源系统体积大、功耗高等难以满足动态测量需求的问题,本研究采用可控呼气振荡与状态可视化反馈的新策略,设计了微型电磁振荡源、集成传感控制电路和动态反馈系统,开发了一种结构轻巧、功耗低及带可视化状态反馈的气道阻抗监测系统。呼吸阻抗测量实验及统计对比结果表明,该系统可实现稳定的5 Hz气道阻抗测量,呼吸系统阻抗(R和X)频谱曲线与临床肺功能仪IOS的频谱曲线均具有较为一致的变化趋势,其差值均小于1.1 cm H_(2)O·s/L;运动与静息状态组的呼吸阻抗R5差异有统计学意义,且呼吸电抗X5的波动幅值较大,表明本系统能测量气道阻力参数的动态变异性。因此,本研究开发的阻抗监测系统支持受试者可手持移动、较长时间段内连续测量气道阻抗的动态变化,为进一步开发低功耗、便携化甚至可穿戴的动态肺功能监测设备提供了研究基础。Monitoring airway impedance has significant clinical value in accurately assessing and diagnosing pulmonary function diseases at an early stage.To address the issue oflarge oscillator size and high power consumption in current pulmonary function devices,this study adopts a new strategy of expiration-driven oscillation.A lightweight and low-power airway impedance monitoring system with integrated sensing,control circuitry,and dynamic feedback system,providing visual feedback on the system's status,was developed.The respiratory impedance measurement experiments and statistical comparisons indicated that the system could achieve stable measurement of airway impedance at 5 Hz.The frequency spectrum curves of respiratory impedance(R and X)showed consistent trends with those obtained from the clinical pulmonary function instrument,specifically the impulse oscillometry system(IOS).The differences between them were all less than 1.1 cm H_(2)O·s/L.Additionally,there was a significant statistical difference in the respiratory impedance R5 between the exercise and rest groups,which suggests that the system can measure the variability of airway resistance parameters during exercise.Therefore,the impedance monitoring system developed in this study supports subjects in performing handheld,continuous measurements of dynamic changes in airway impedance over an extended period of time.This research provides a foundation for further developing low-power,portable,and even wearable devices for dynamic monitoring of pulmonary function.

关 键 词：动态肺功能 呼吸阻抗 振荡源 呼气正压 可视化反馈 

分 类 号：TH77[机械工程—仪器科学与技术]