基于三周期极小曲面法骨小梁支架的设计与性能研究  

Design and performance study of bone trabecular scaffolds based on triply periodic minimal surface method

作　　者：门玉涛[1,2] 汤绍灿 陈炜[1,2] 刘福龙 张春秋[1,2] MEN Yutao;TANG Shaocan;CHEN Wei;LIU Fulong;ZHANG Chunqiu(Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control,School of Mechanical Engineering,Tianjin Universityof Technology,Tianjin300384,P.R.China;National Demonstration Center for Experimental Mechanical and Electrical Engineering Education,Tianjin University of Technology,Tianjin 300384,P.R.China)

机构地区：[1]天津理工大学天津市先进机电系统设计与智能控制重点实验室,天津300384 [2]天津理工大学机电工程国家级实验教学示范中心,天津300384

出　　处：《生物医学工程学杂志》2024年第3期584-594,共11页Journal of Biomedical Engineering

基　　金：国家自然科学基金面上项目(12072235);天津市研究生科研创新资助项目(2022SKYZ145)。

摘　　要：三周期极小曲面(TPMS)可以通过公式精确地控制多孔支架的形态而被广泛应用。本文构建一种I型包装(I-WP)型多孔支架,采用有限元法研究壁厚和周期与支架形态和力学性能的关系,并进行压缩和流体性能的研究。研究发现,不同壁厚(0.1~0.2 mm)、不同周期(I-WP 1~I-WP 5)的I-WP型支架孔隙率在68.01%~96.48%范围内,等效弹性模量为0.655~18.602 GPa;随着周期和壁厚的增加,支架应力分布趋于均匀;拓扑优化后I-WP型支架等效弹性模量基本不变,渗透性提升52.3%。综上,对于I-WP型支架可以先调控周期参数,后调控壁厚参数,结合拓扑优化来达到设计要求。本文构建的I-WP型支架具有良好的力学性能,且满足修复人体骨组织的需求,为人工骨小梁支架的设计提供一种新选择。Triply periodic minimal surface(TPMS)is widely used because it can be used to control the shape of porous scaffolds precisely by formula.In this paper,an I-wrapped package(I-WP)type porous scaffolds were constructed.The finite element method was used to study the relationship between the wall thickness and period,the morphology and mechanical properties of the scaffolds,as well as to study the compression and fluid properties.It was found that the porosity of I-WP type scaffolds with different wall thicknesses(0.1~0.2 mm)and periods(I-WP 1~I-WP 5)ranged from 68.01%~96.48%,and the equivalent elastic modulus ranged from 0.655~18.602 GPa;the stress distribution of the scaffolds tended to be uniform with the increase of periods and wall thicknesses;the equivalent elastic modulus of the IWP type scaffolds was basically unchanged after the topology optimization,and the permeability was improved by 52.3%.In conclusion,for the I-WP type scaffolds,the period parameter can be adjusted first,then the wall thickness parameter can be controlled.Topology optimization can be combined to meet the design requirements.The I-WP scaffolds constructed in this paper have good mechanical properties and meet the requirements of repairing human bone tissue,which may provide a new choice for the design of artificial bone trabecular scaffolds.

关 键 词：三周期极小曲面 多孔支架 拓扑优化 结构强度 渗透性 

分 类 号：R318.08[医药卫生—生物医学工程]