PCSK9在心血管疾病中的研究进展  

Research progress on role of PCSK9 in cardiovascular disease

作　　者：杜林芳 练静 李阳 魏晓丽[1] 马恒 DU Lin-fang;LIAN Jing;LI Yang;WEI Xiao-li;MA Heng(School of Basic Medicine,Yan’an University,Yan’an 710600,Shaanxi,China;School of Basic Medicine,Shaanxi University of Traditional Chinese Medicine,Xianyang 712046,Shaanxi,China;Department of Physiology and Pathophysiology,School of Basic Medical Sciences,Air Force Medical University,Xi’an 710032,Shaanxi,China)

机构地区：[1]延安大学基础医学院,陕西延安710600 [2]陕西中医药大学基础医学院,陕西咸阳712046 [3]空军军医大学基础医学院生理与病理生理学教研室,陕西西安710032

出　　处：《心脏杂志》2024年第3期324-328,共5页Chinese Heart Journal

基　　金：国家自然科学基金项目(82070261,82170251,82100312)。

摘　　要：前蛋白转化酶枯草溶菌素9(protein convertase subtilisin/kexin type 9,PCSK9)是一种丝氨酸蛋白酶,主要产生于肝脏。作为前蛋白转化酶家族中的一员,PCSK9可以与低密度脂蛋白受体(low-density lipoprotein receptor,LDLR)结合使其进入溶酶体进行降解,从而抑制LDLR再循环到细胞表面发挥清除血浆中的低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)的功能,进而导致高胆固醇血症。近年的研究显示PCSK9与心血管疾病的发生发展有着紧密的联系,所以PCSK9在心血管疾病研究中显示出作为新治疗靶点的可能性。本文以PCSK9为切入点,总结论述其结构、功能并概述了PCSK9在多种心血管疾病中的研究进展。Proprotein convertase subtilisin/kexin type 9(PCSK9)is a serine protease that is produced mainly in the liver.As a member of the proprotein convertase family,PCSK9 binds to the LDL receptor(low-density lipoprotein receptor(LDLR)to allow it to enter the lysosome for degradation,thereby inhibiting the recirculation of LDLR to the cell surface for removal of plasma LDL cholesterol(low-density lipoprotein cholesterol,LDL-C).This inhibits the recirculation of LDLR to the cell surface to perform the function of removing low-density lipoprotein cholesterol(LDL-C)from plasma,which leads to hypercholesterolemia.Existing studies have shown that PCSK9 is closely associated with the development of various cardiovascular diseases and has shown the potential as a new therapeutic target in cardiovascular disease research.Here,we summarize the structure and function of PCSK9 as an entry point and review the progress of PCSK9 research in various cardiovascular diseases.

关 键 词：前蛋白转化酶枯草溶菌素9 LDL受体 心血管疾病 

分 类 号：R331.3[医药卫生—人体生理学] R34[医药卫生—基础医学]