同型半胱氨酸在诊断脊髓亚急性联合变性中的预测价值  

The predictive value of homocysteine in the diagnosis of subacute combined degeneration of spinal cord

作　　者：王芳[1] 覃彬 韦建萍 曾伟 翁映虹[1] WANG Fang;QIN Bin;WEI Jianping;ZENG Wei;WENG Yinghong(Department of Neurology,Liuzhou People’s Hospital,Liuzhou 545001,Guangxi,China)

机构地区：[1]广西柳州市人民医院神经内科,广西柳州545001

出　　处：《右江民族医学院学报》2024年第3期351-354,共4页Journal of Youjiang Medical University for Nationalities

基　　金：广西壮族自治区卫生和计划生育委员会自筹经费科研课题(Z20180316)。

摘　　要：目的研究同型半胱氨酸(homocysteine,Hcy)在诊断脊髓亚急性联合变性(subacute combined degeneration of spinal cord,SCD)中的预测价值。方法采用回顾性分析研究,选取2014年11月至2023年6月在柳州市人民医院神经内科住院的SCD患者74例及同期住院非SCD患者71例为对照组,收集两组的血清Hcy水平。采用SPSS 26.0统计学软件进行相关数据统计分析。采用接收者操作特征评价曲线评价血Hcy对SCD的预测价值。结果SCD患者Hcy水平[53.35(13.40~106.83)μmol/L]明显高于对照组[13.20(10.00~14.90)μmol/L],两组间差异具有统计学意义(P<0.001)。采用接收者操作特征评价曲线血浆Hcy浓度对SCD的预测价值,曲线下面积AUC为0.805(95%CI:0.728~0.882)。结论SCD患者Hcy均较对照组显著升高,在预测SCD发病风险方面有潜在应用价值。Objective To investigate the predictive value of homocysteine(Hcy)in the diagnosis of subacute combined degeneration of the spinal cord(SCD).Methods A retrospective analysis was conducted on 74 SCD patients hospitalized in the Department of Neurology at Liuzhou People’s Hospital from November 2014 to June 2023,compared with 71 non-SCD patients hospitalized during the same period serving as the control group.Serum Hcy levels were collected from both groups.SPSS 26.0 software was used for statistical analysis.The receiver operating characteristic(ROC)curve was used to evaluate the predictive value of blood Hcy for SCD.Results The Hcy level in SCD patients[53.35(13.40~106.83)μmol/L]was significantly higher than that in the control group[13.20(10.00~14.90)μmol/L],with a statistically significant difference between the two groups(P<0.001).The ROC curve analysis showed that the area under the curve(AUC)for plasma Hcy concentration in predicting SCD was 0.805(95%CI:0.728~0.882).Conclusion Hcy levels in SCD patients are significantly higher than that of the control group,indicating potential application value in predicting the risk of SCD.

关 键 词：高同型半胱氨酸血症 脊髓亚急性联合变性 诊断 

分 类 号：R544.1[医药卫生—心血管疾病]