Visible-Light-Driven Four-Component Radical Relay Aminocarbonylation of Unactivated Alkenes  

作　　者：Bin Lu Feng-Shuo Bao Zi-Wei He Wen-Jing Xiao Jia-Rong Chen 

机构地区：[1]Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction,College of Chemistry,CentralChina Normal University,152 Luoyu Road,Wuhan,Hubei 430079,China [2]Wuhan Institute of Photochemistry and Technology,7North Bingang Road,Wuhan,Hubei 430083,China [3]Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province,Gannan Normal University,Ganzhou,Jiangxi 341000,China

出　　处：《Chinese Journal of Chemistry》2024年第9期990-996,共7页中国化学（英文版）

基　　金：the financial support from the National Natural Science Foundation of China(21971081,22171099,21820102003,91956201,22203034,and 92256301);the Double-Thousand Talents Plan of Jiangxi Province(jxsq2023102004);the Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University(2021YB02);and the Program of Introducing Talents of Discipline to Universities of China(111 Program,B17019).

摘　　要：Catalytic four-component radical carbonylation of unactivated alkenes has recently been recognized as a robust protocol for rapid construction of various structurally diverse carbonyl compounds.Given the significance of fluorine-containing groups,this reaction class has been extensively applied to assembly of a variety of perfluoroalkyl carboxylic acid derivatives by transition metal catalysis.Herein,we report a visible-light-driven radical relay 1,2-perfluoroalkylation aminocarbonylation of unactivated alkenes using CO gas as carbonyl source and 4CzIPN as organic photocatalyst.A wide range of alkenes and amines were well tolerated,providing the valuableβ-perfluoroalkylated amides with generally good yields and high chemoselectivity.

关 键 词：Visible light Photoredox catalysis Radical aminocarbonylation Multicomponent reaction Carbon monoxide Unactivated alkenes AmidesIReactionmechanisms 

分 类 号：O62[理学—有机化学]