Recent Advances in C-F Bond Formation from Carbon-Centered Radicals  

作　　者：Jihua Zhang Juanjuan Wang Qiang Cheng 

机构地区：[1]College of Chemistry and Molecular Sciences,Wuhan University,Wuhan,Hubei 430072,China

出　　处：《Chinese Journal of Chemistry》2024年第9期1009-1031,共23页中国化学（英文版）

基　　金：the National Natural Science Foundation of China(22301224);Wuhan Science and Technology Project(2023020201020273),and Wuhan University for financial support.We thank Prof.Wen-Bo Liu(Wuhan University)for proof reading.

摘　　要：Construction of C-F bonds is a direct and efficient method for introducing fluorine into pharmaceuticals,agrochemicals,and materials.Strategies such as nucleophilic,electrophilic,radical,and transition-metal catalyzed fluorination have been developed to meet the demand of diverse C-F bond formation.Among them,radical fluorination has been witnessed with substantial advancement in a recent decade.Herein,we reviewed methods for formation of C-F bonds with carbon-centered radicals as key intermediates,especially in recent five years.We introduce in the paper with different fluorinating reagents,strategies for radical generation,and application in late-stage functionalization and synthesis of PET tracers.We also indicate the current limitations and propose the direction of the field for the future development.

关 键 词：FLUORINE Fluorinating reagents Late-stage fluorination [^(18)F]jfluorination Radical reactions Synthetic methods 

分 类 号：O62[理学—有机化学]