The potential of starch-chitosan blends with poloxamer for the preparation of microparticles by spray-drying  

作　　者：Juan Enrique Barranco-García Carolina Caicedo Enrique Javier Jiménez-Regalado Carlos Espinoza-González Graciela Morales Rocio Yaneli Aguirre-Loredo Abril Fonseca-García 

机构地区：[1]Tecnológico Nacional de México/Instituto Tecnológico de Oaxaca,Departamento de Química y Bioquímica,Avenida Ing.Víctor Bravo Ahuja No.125,Esquina Calzada Tecnológico,68030,Oaxaca,Mexico [2]Faculty of Engineering,Unidad Central del Valle del Cauca(UCEVA),Carrera 17a 48-144,763022,Tuluá,Colombia [3]Centro de Investigación en Química Aplicada(CIQA),Blvd.Enrique Reyna Hermosillo 140,25294,Saltillo,Coahuila,Mexico [4]Investigadoras por México CONAHCYT-CIQA,Av.Insurgentes Sur 1562,Col.Crédito Constructor,03940,Alcaldía Benito Juárez,CDMX,Mexico

出　　处：《Particuology》2024年第6期1-10,共10页颗粒学报（英文版）

基　　金：supporting the financing of this study through project 6710(Internal call 2022).

摘　　要：Using biopolymers as wall materials in spray drying poses challenges,particularly in attaining flowability and thermal stability among their physicochemical properties.This paper addresses these challenges by preparing microparticles using a blend of starch–chitosan and a poloxamer,commercially named Pluronic®F127.We aimed to elucidate the effects of varying poloxamer concentrations on the resulting particles through the spray drying technique.Blends with a poloxamer concentration of 3%(w/v)demonstrated a notably higher yield,especially when compared to those with 0%and 1%concentrations.Microparticles with 3%and 5%(w/v)poloxamer displayed a narrower particle size distribution,with the 3%blend showing a superior yield attributed to arrangements of blend components that improve flowability.X-ray diffraction analysis showcased the characteristic peaks of A-type starch form,with shifts suggesting enhanced interactions between components.Microparticles with increased poloxamer content showed elevated thermal degradation temperatures,with the 3%blend registering a significant rise,opening avenues for encapsulating heat-sensitive bioactive.This study primarily focuses on the preparation and basic characterization of microparticles.It underscores the potential of blends with optimal poloxamer concentrations in microencapsulation,emphasizing further research to harness their capabilities thoroughly.

关 键 词：BIOPOLYMER Starch CHITOSAN Pluronic®F127 MICROPARTICLES Spray drying 

分 类 号：O63[理学—高分子化学]