糖尿病肾脏病发病机制的探讨  

Research progress on pathogenesis of diabetic kidney disease

作　　者：赵津[1] 蔡永红[1] 张莲[1] 刘建峰[1] 赵克中[1] Zhao Jin;Cai Yonghong;Zhang Lian;Liu jinfeng;Zhao kezhong(Department of Renal En-docrinology,Jinghai Clinical College,Tianjin Medical University,Tianjin 301600,China)

机构地区：[1]天津医科大学静海临床学院肾脏内分泌科,天津301600

出　　处：《国际内分泌代谢杂志》2024年第3期189-193,共5页International Journal of Endocrinology and Metabolism

摘　　要：糖尿病肾脏病(DKD)是糖尿病最常见的并发症之一,也是终末期肾脏病(ESKD)的主要原因。它的发生和发展涉及3个基本组成部分:血流动力学异常、代谢紊乱和炎症反应。临床上定义该病为伴有肾小球滤过率(eGFR)进行性下降的持续性蛋白尿。然而,由于这些改变不是DKD所特有的,因此有必要从发病机制中探讨新的生物标志物,有助于DKD患者的早期诊断、随访、治疗反应和预后评估。Diabetic kidney disease(DKD)is one of the most common complications of diabetes mellitus and the main cause of end-stage renal disease(ESKD).Its development involves three fundamental components:the hemodynamic abnormality,metabolic disorder,and inflammatory response.Clinically,persistent albuminuria in association with a progressive decline in glomerular filtration rate(GFR)defines this disease.However,as these alterations are not specific to DKD,there is a need to discuss novel biomarkers arising from its pathogenesis which may aid in the diagnosis,follow-up,therapeutic response,and prognosis of the disease.

关 键 词：生物标志物 糖尿病肾脏病 发病机制 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]