皮肤与骨质疏松症  

Skin and Osteoporosis

作　　者：杨泓娟 龚恬 项守奎[1] Yang Hongjuan;Gong Tian;Xiang Shoukui(Department of Endocrinology,the Third Affiliated Hospital of Soochow University,Changzhou 213003,China)

机构地区：[1]苏州大学附属第三医院内分泌代谢科,常州213003

出　　处：《国际内分泌代谢杂志》2024年第3期202-205,共4页International Journal of Endocrinology and Metabolism

基　　金：常州市医学拔尖人才项目(2022260)。

摘　　要：骨质疏松症是一种以骨量低下,骨组织微结构损坏,导致骨脆性增加,易发生骨折为特征的全身性骨病。皮肤作为人体最大的器官,皮肤结构的相关参数可作为预测骨质疏松症的标志物,例如皮肤厚度、皮肤弹性、体表面积等。研究证明,与皮肤疾病相关的一些炎症因子以及治疗药物影响着骨重塑的平衡;皮肤老化与骨量流失存在一定的相关性,雌激素、晚期糖基化终产物和胱抑素A可能在两者之间发挥着重要作用。本文旨在对皮肤与骨质疏松症的相关性进行综述,进而为骨质疏松症的诊治提供新思路。Osteoporosis is a systemic bone disease characterized by low bone mass and deterioration of bone microstructure,leading to increased bone fragility and susceptibility to fracture.As the largest organ of the body,structurally relevant parameters of the skin can be used as markers to predict osteoporosis,such as skin thickness,skin elasticity,body surface area,etc.It has been demonstrated that some inflammatory factors and therapeutic drugs associated with skin diseases affect the balance of bone remodeling.There is a certain correlation between skin aging and bone mass loss,and estrogen,advanced glycosylation end products and cystatin A may play an important role in them.The aim of this paper is to review the correlation between skin and osteoporosis,and thus provide new ideas for the diagnosis and treatment of osteoporosis.

关 键 词：骨质疏松症 皮肤结构 皮肤疾病 炎性因子 老化 

分 类 号：R580[医药卫生—内分泌]