从肠道微生物论健脾益气法治疗桥本甲状腺炎  

Treatment of Hashimoto thyroiditis by strengthening the spleen and replenishing qi from the view of intestinal flora

作　　者：谭艳 贾思锋 左新河[1,2] 谢敏 付畅 赵勇[2] TAN Yan;JIA Sifeng;ZUO Xinhe;XIE Min;FU Chang;ZHAO Yong('Hubei University of Traditional Chinese Medicine,Wuhan,Hubei 430065,China;不详)

机构地区：[1]湖北中医药大学,湖北武汉430065 [2]湖北省中医院

出　　处：《中国微生态学杂志》2024年第5期617-620,F0003,共5页Chinese Journal of Microecology

基　　金：国家中医药管理局第三届全国名中医传承工作室项目(国中医药办人教函[2018]119号);学术流派传承工作室第二轮建设项目(国中医药人教函[2019]62号)。

摘　　要：桥本甲状腺炎(Hashimoto thyroiditis,HT)是临床常见的自身免疫性甲状腺疾病,中医常从脾论治HT,以健脾益气法为治疗原则。现代研究表明,肠道微生物失调可刺激免疫反应,诱发HT。中医的脾在生理功能和病理表现上与肠道菌群极为相似。诸多研究表明健脾益气类中药能改善微生物群失调,调节肠道微生物群结构及多样性,纠正有益菌和有害菌的比例失调,维持微生物群的动态平衡,调节机体代谢。本文从肠道微生物的角度探讨从脾论治HT的现代科学机制,以期为中医药治疗HT提供更多的理论基础。Hashimoto thyroiditis(HT)is a clinically common autoimmune thyroid disease.Traditional Chinese medicine(TCM)often treats HT from the spleen,and the principle of treatment is to strengthen the spleen and replenish qi.Modern research showed that intestinal flora imbalance can stimulate immune response and induce HT.The"spleen"by TCM is very similar to the intestinal flora in physiological function and pathological manifestations.Many studies have shown that TCM formulas for invigorating the spleen and replenishing qi can improve the imbalance of intestinal flora,regulate the structure and diversity of intestinal flora,correct the imbalanced proportion of probiotics to harmful bacteria,maintain the dynamic balance of intestinal flora,and regulate the metabolisms of the body.This article discussed modern scientific mechanisms of treating HT from the spleen from the perspective of intestinal flora,in order to provide more theoretical basis for treating HT with traditional Chinese medicine.

关 键 词：肠道微生物 桥本甲状腺炎 从脾论治 

分 类 号：R259[医药卫生—中西医结合]