不同频率全身振动训练对去卵巢大鼠学习记忆能力的影响及其机制  

Effects of whole body vibration training at different frequencies on learning and memory ability in ovariectomized rats and their mechanisms

作　　者：何利民 张静 解俊樊 代亚非 HE Li-min;ZHANG Jing;XIE Jun-fan;DAI Ya-fei(Section of Physical Education,Lanzhou University,Lanzhou 730000,China;College of Physical Education and Health,Nanning Normal University,Nanning 530100,China)

机构地区：[1]兰州大学体育教研部,兰州730000 [2]南宁师范大学体育与健康学院,南宁530100

出　　处：《兰州大学学报（自然科学版）》2024年第3期403-408,共6页Journal of Lanzhou University(Natural Sciences)

基　　金：中央高校基本科研业务费专项基金(2019jbkyzy020);广西高校中青年教师科研基础能力提升项目(2021KY0403);南宁师范大学博士科研启动基金项目。

摘　　要：探讨不同频率全身振动训练(WBV)对去卵巢大鼠学习记忆能力的影响及其机制.将40只雌性SD大鼠分为假手术组(Sham组)、去卵巢安静组(OVX组)、去卵巢+高频全身振动训练组(HWBV组,35Hz)和去卵巢+低频全身振动训练组(LWBV组,15Hz).采用水迷宫试验检测各组大鼠的学习和记忆能力,检测各组大鼠血清、前额叶皮质、大脑皮层和海马中脑源性神经营养因子(BDNF)的水平及谷胱甘肽过氧化物酶(GPx)、总超氧化物歧化酶(SOD)的活性.结果表明,与Sham组相比,OVX组大鼠表现为空间学习能力障碍和短期记忆能力障碍,高频WBV可改善去卵巢大鼠的学习及记忆障碍,低频WBV只有微弱的改善作用;OVX组大鼠血清、前额叶皮质、大脑皮层和海马中BDNF水平、 GPx和SOD活性显著降低;HWBV组大鼠血清、前额叶皮质、大脑皮层和海马中BDNF水平、 GPx和SOD活性显著高于OVX和LWBV组.高频WBV可改善去卵巢大鼠的学习和记忆障碍,其机制可能与其增加大鼠血清及各脑区中BDNF及抗氧化作用有关.To investigate the effects of different-frequency whole body vibration training(WBV) on learning and memory ability of ovariectomized rats and its mechanism,40 female SD rats were divided into a sham operation group(Sham group),ovariectomy group(OVX group),ovariectomy+high frequency whole body vibration training group(HWBV group,35 Hz) and ovariectomized+low frequency whole body vibration training group(LWBV group,15 Hz).A water maze test was used to test the learning and memory ability of each group of rats,and the levels of brain-derived neurotrophic factor(BDNF) and activities of glutathione peroxidase(GPx) and superoxide dismutase(SOD) in serum,prefrontal cortex,cerebral cortex and hippocampus were detected.The results showed that,compared with the Sham group,the OVX group showed spatial learning disabilities and short-term memory impairment.High-frequency WBV improved these learning and memory impairment in ovariectomized rats,while low-frequency WBV only had a slight improvement.Compared with the Sham group,the levels of BDNF in the serum,prefrontal cortex,cerebral cortex and hippocampus of the OVX group were significantly decreased,and activities of GPx and SOD significantly decreased.The levels of BDNF and GPx and SOD in serum,prefrontal cortex,cerebral cortex and hippocampus of the HWBV group were significantly higher than those of the OVX and LWBV group.High-frequency WBV could improve learning and memory impairment in ovariectomized rats,which mechanism might be related to the increase of BDNF and anti-oxidation in rat serum and brain regions.

关 键 词：全身振动训练 去卵巢大鼠 学习记忆 水迷宫试验 

分 类 号：G804.2[文化科学—运动人体科学]