Solriamfetol的二维相关红外光谱分析  

Analysis of Solriamfetol's Generalized Two-dimensional Correlation Infrared Spectroscopy

作　　者：周伟明[1] 刘浩[1] 王如意[1] ZHOU Wei-ming;LIU Hao;WANG Ru-yi(Guangdong Food and Drug Vocational College,Guangdong Guangzhou 510520,China)

机构地区：[1]广东食品药品职业学院,广东广州510520

出　　处：《广州化工》2024年第5期127-131,共5页GuangZhou Chemical Industry

基　　金：广东省医学科研基金(B2020170);广东省普通高校特色创新项目(2020KTSCX259);广东食品药品职业学院自然科学基金(2020ZR13)。

摘　　要：利用红外光谱及二维相关光谱进行了Solriamfetol进行了结构分析。检测Solriamfetol 20~150℃范围内(每隔5℃)的近红外光谱,结合红外光谱、二维相关光谱及相关文献,分析Solriamfetol分子内变化。观察分析了温度对Solriamfetol分子的羰基、脂肪胺基和酰胺基的氢键和自由基之间的影响,明确了因温度扰动,引起羰基氢键的断裂及变化规律,分析了胺基与酰胺氢键的不同,确定了不同分结构之间的变化先后顺序,并进行了红外峰的归属。联合使用二相关光谱,提高了Solriamfetol红外光谱的分辨率和可解释性。Infrared spectroscopy and two-dimensional correlation spectroscopy were used to analyze the structure of solriamfetol.Infrared spectroscopy in the range of 20~150℃(at 5℃intervals)were firstly examined,and the intramolecular changes of Solriamfetol were analyzed in combination with infrared spectroscopy,two-dimensional correlation spectroscopy and related literature.The effects of temperature on the hydrogen bonds and free radicals between the carbonyl,aliphatic amine and amide groups of Solriamfetol molecule were observed and analyzed.The breakage and change pattern of carbonyl hydrogen bonds due to temperature perturbation were clarified,and the difference between amine and amide hydrogen bonds were analyzed to determine the sequence of changes between different substructures,and the attribution of infrared peaks was performed.The resolution and interpretability of the Solriamfetol infrared spectroscopy were improved by the joint use of two-dimensional correlation spectroscop.

关 键 词：红外光谱 二维相关光谱 Solriamfetol 

分 类 号：R913[医药卫生—药学]