硒、铁、锌和铜对动物健康的影响及其对表观遗传调控机制的研究进展  

Research Progress on Effects of Selenium,Iron,Zinc and Copper on Animal Health and Their Epigenetic Regulatory Mechanisms

作　　者：张菁怡 阮记明[1] 殷超 黄建珍[1] ZHANG Jingyi;RUAN Jiming;YIN Chao;HUANG Jianzhen(College of Animal Science and Technology,Jiangxi Agricultural University,Nanchang 330045,China)

机构地区：[1]江西农业大学动物科学技术学院,南昌330045

出　　处：《动物营养学报》2024年第6期3563-3572,共10页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家自然科学基金(32360867,31960690);江西农业大学青年创新团队项目(JXAUCXTD007)。

摘　　要：微量矿物元素(微量元素)少量存在于动物机体中,但对机体生理功能至关重要。研究证明,微量元素通过表观遗传调控对动物机体产生影响,起到提高动物生产力、防治动物疾病的作用,可降低饲养成本、提高动物产品(肉、蛋和奶等)质量。表观遗传学的定义为不依赖于DNA序列变化而导致染色体变化的、可遗传基因表达变化的现象和机制,是近年来研究的一大热点,其调控机制包括DNA甲基化、组蛋白修饰和非编码RNA调控等。本文主要论述常见的几种微量元素硒、铁、锌和铜对动物健康的影响及其表观遗传的调控作用和机制,以期为之后的研究和应用提供一定参考。Trace mineral elements(referred to as trace elements)exist in a small amount in the animal body,but they are vital to the physiological function of the body.Research has proved that trace elements through epigenetic regulation on the animal body impact,play a role in improving animal productivity,prevention and control of animal diseases,can reduce feeding costs,improve the quality of animal products(meat,eggs and milk,etc.).Epigenetics is defined as the phenomenon and mechanism of heritable gene expression changes that lead to chromosomal changes independent of DNA sequence changes.It has been a hot research topic in recent years,and its regulatory mechanisms include DNA methylation,histone modification and regulation of non-coding RNA,etc.This paper mainly discusses the effects of common trace elements such as selenium,iron,zinc and copper on animal health and their epigenetic regulation and mechanism,in order to provide some reference for future research and application.

关 键 词：表观遗传 微量元素 DNA甲基化 组蛋白修饰 非编码RNA 

分 类 号：S811.2[农业科学—畜牧学]