基于数据挖掘方法分析阮岩治疗儿童变应性鼻炎的用药规律  

Analysis on Medication Rule of Ruan Yan in the Treatment of Children with Allergic Rhinitis Based on Data Mining

作　　者：徐玮祯 王思敏 方彩珊 蓝婉宁 阮岩[3,4] 闫亚杰 孟瑜 王睿智 朱锦祥 张嘉骏 刘沁东 何伟平 徐慧贤[3,4] XU Weizhen;WANG Simin;FANG Caishan;LAN Wanning;RUAN Yan;YAN Yajie;MENG Yu;WANG Ruizhi;ZHU Jinxiang;ZHANG Jiajun;LIU Qindong;HE Weiping;XU Huixian(The First Clinical Medical College of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;Clinical Medical College of Chengdu University of Traditional Chinese Medicine,Chengdu 610000 Sichuan,China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;Guangdong Clinical Research Academy of Chinese Medicine,Lingnan Institute of Otolaryngology,Guangzhou 510405 Guangdong,China;Shenzhen Traditional Chinese Medicine Hospital,Shenzhen 518033 Guangdong,China)

机构地区：[1]广州中医药大学第一临床医学院,广东广州510405 [2]成都中医药大学临床医学院,四川成都610000 [3]广州中医药大学第一附属医院,广东广州510405 [4]广东省中医临床研究院岭南耳鼻喉病研究所,广东广州510405 [5]深圳市中医院,广东深圳518033

出　　处：《中药新药与临床药理》2024年第6期896-903,共8页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家自然科学基金项目(82274590,82305325,81974581);广东省基础与应用基础研究基金项目(2021A1515110446);广州市科技基础与应用基础研究项目(202201011211);2020年阮岩省名中医传承工作室项目(2100600145);国家中医药管理局2023年中医药循证能力提升项目;广州市科技计划项目(202201020308)。

摘　　要：目的以数据挖掘的方法分析阮岩教授治疗儿童变应性鼻炎的组方用药规律,为治疗儿童变应性鼻炎的临床实践及成药研发提供参考。方法收集阮岩教授治疗儿童变应性鼻炎的门诊医案,运用Microsoft Excel 2010软件进行频数统计,运用SPSS Clementine 12.0软件进行关联规则分析、聚类分析、因子分析等数据挖掘方法,获得药物的使用频次及药物之间的关联规则,分析处方中的用药组方规律。结果共收集处方308首,中医证型分布以肺气虚寒证和肺脾气虚证为主,涉及中药80种,高频中药以解表药和补气药为主,药物性味以辛甘温为主,多归肺脾胃经;聚类分析得到4个潜在的核心基础方,因子分析得到5个核心药方。结论阮岩教授临床治疗儿童变应性鼻炎以宣肺通窍、祛风散寒、健脾益气为基本治疗方法,在变应性鼻炎发作期多以驱邪为主,宣肺通窍、祛风散寒;缓解期则以“治病求本”为主要原则,从改善儿童体质入手,补肺健脾,以治其本。Objective To analyze and discuss the medication rule of professor Ruan Yan in the treatment of children with allergic rhinitis by using data mining method,and to provide reference for the clinical research and patented drugs development for the treatment of children with allergic rhinitis.Methods The outpatient medical records of professor Ruan Yan for the treatment of children with allergic rhinitis were collected.Microsoft Excel 2010 software was used for frequency statistics.SPSS Clementine 12.0 software was used for association rule analysis,cluster analysis and factor analysis to obtain the data.The frequency of use of various drugs and the association rules between drugs were obtained.Then the medication rules in professor Ruan Yan’s prescription were analyzed.Results A total of 308 Chinese medicine compounds were included,involving 80 kinds of Chinese medicines,among which relieving drugs and qi-invigorating herbs were high-frequently used.The distribution of traditional Chinese medicine syndrome types was mainly characterized by lung-qi deficiency-cold syndrome and lung-spleen qi deficiency syndrome.The medicinal properties were mainly spicy,warm and sweet,and most of them belonged to the lung,spleen and stomach meridians.Five core prescriptions were extracted by factor analysis.Four drug combinations were obtained by systematic cluster analysis.Conclusion Ventilating lung and opening the orifices,expelling wind and removing cold,strengthening the spleen and replenishing qi are basic therapeutic principles for professor Ruan Yan in the treatment of children with allergic rhinitis.The treatment mainly focused on dispelling evil,ventilating lung and opening the orifices,expelling wind and removing cold during the acute stage of allergic rhinitis.In the remission period,according to the principle of“treating disease must be based on its origin”,the treatment should enhance children’s physical fitness,tonify lung and strengthen spleen,thereby reducing recurrence.

关 键 词：变应性鼻炎 儿童 中医药 数据挖掘 用药规律 宣肺通窍 祛风散寒 健脾益气 

分 类 号：R285.6[医药卫生—中药学]