山茱萸提取物抗肿瘤作用机制的研究进展  

Research progress on anti-tumor mechanism of Cornus officinalis extract

作　　者：张月明 罗雅琴[2] 张玉梅 刘奎[2] 丁继元 王敬毅[2] ZHANG Yueming;LUO Yaqin;ZHANG Yumei;LIU Kui;DING Jiyuan;WANG Jingyi(The First College of Clinical Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250000,China;Department of Hematology,Affliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250000,China)

机构地区：[1]山东中医药大学第一临床医学院,济南250000 [2]山东中医药大学附属医院血液科,济南250000

出　　处：《中华中医药杂志》2024年第6期3010-3013,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金青年科学基金项目(No.82104609);山东省医药卫生科技发展计划项目(No.202003041150)。

摘　　要：中药山茱萸是山茱萸的干燥成熟果肉,化学活性成分主要包括环烯醚萜苷类、鞣质类、黄酮类、三萜类、有机酸及其酯类、多糖类等。随着对其药理作用的深入研究,山茱萸及其提取物已被证实具有保护心脏、保护神经、抗氧化、抗肿瘤、抗衰老、抗炎、镇痛、抗骨质疏松、抗健忘、抗抑郁和免疫调节的功效。对山茱萸及其提取物抗肿瘤作用的分子机制研究表明,山茱萸及其提取物可通过诱导肿瘤细胞凋亡、抑制肿瘤细胞增殖、阻滞细胞周期、影响信号通路、调节机体免疫等多种途径发挥抗肿瘤作用。文章将山茱萸及其提取物的抗肿瘤作用机制研究进行归纳整理,以期能为山茱萸及其提取物抗肿瘤治疗提供相应的理论依据。Cornus officinalis is the dried and mature pulp of cornus officinalis.The chemical active components of cornus officinalis mainly include iridoid glycosides,tannins,flavonoids,triterpenoids,organic acids and their esters,and polysaccharides.With the in-depth study of its pharmacological effects,Cornus officinalis and its extracts have been confirmed to have the effects of protecting the heart,protecting nerves,anti-oxidation,anti-tumor,anti-aging,anti-inflammatory,analgesic,antiosteoporosis,anti-amnesia,anti-depression and immune regulation.Studies on the molecular mechanism of the anti-tumor effects of Cornus officinalis and its extracts show that Cornus officinalis and its extracts can induce apoptosis of tumor cells,inhibit proliferation of tumor cells,block cell cycle,affect signal pathway,regulate immunity and so on.In this review,the anti-tumor mechanism of Cornus officinalis and its extracts is summarized,in order to provide theoretical basis for the anti-tumor treatment of Cornus officinalis and its extracts.

关 键 词：山茱萸提取物 抗肿瘤 抗白血病 细胞凋亡 细胞增殖 细胞周期 信号通路 免疫调节 

分 类 号：R285[医药卫生—中药学]