不同捻转手法对全脑功能连接的影响  

Effects of different acupuncture twist manipulation on whole-brain functional connectivity

作　　者：周以皓 冯斯峰 董旭[3] 王东岩[3] 施静 ZHOU Yihao;FENG Sifeng;DONG Xu;WANG Dongyan;SHI Jing(Heilongjiang University of Chinese Medicine,Harbin 150040,China;The First Affliated Hospital of Yunnan University of Chinese Medicine/Yunnan Provincial Hospital of Traditional Chinese Medicine,Kunming 650021,China;The Second Affliated Hospital,Heilongjiang University of Chinese Medicine,Harbin 150001,China)

机构地区：[1]黑龙江中医药大学,哈尔滨150040 [2]云南中医药大学第一附属医院/云南省中医医院,昆明650021 [3]黑龙江中医药大学附属第二医院,哈尔滨150001

出　　处：《中华中医药杂志》2024年第6期3187-3191,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81760893);黑龙江省自然科学基金联合引导项目(No.LH2019H113);黑龙江中医药大学创新团队建设项目(No.2017sit01)。

摘　　要：目的:从功能整合角度观察并探索不同捻转手法对健康受试者全脑功能连接的影响。方法:将40名健康志愿者随机分为对照组和试验组,试验组再按照不同的捻转频率,分为120 r/min组、180 r/min组、240 r/min组,每组10名。针刺得气后按不同手法行针,对照组仅针刺不予手法操作。采用视觉模拟量表(VAS)评价针刺感受,基于fMRI和独立成分分析(ICA)比较全脑功能连接差异。结果:VAS结果显示,除沉重感外,各组酸感、胀感、麻感、痛感的组间比较差异有统计学意义(P<0.01)。ICA结果显示,行针后,120 r/min组受试者眶部额上回全脑功能连接强度减弱,180 r/min组受试者额内侧回全脑功能连接强度减弱,240 r/min组受试者颞中回全脑功能连接强度增强,对照组全脑功能连接无显著性变化。与对照组比较,120 r/min组受试者在距状裂周围皮层局部全脑功能连接强度减弱,180 r/min组受试者在中央旁小叶局部全脑功能连接强度增强,240 r/min组受试者在颞上回、楔前叶、额上回局部全脑功能连接强度减弱。结论:不同捻转手法对受试者的针刺感受和全脑功能连接影响存在差异,初步预测了不同的捻转手法可能通过介导不同脑区的神经功能活动从而发挥不同的针刺疗效。Objective:To observe and investigate the response of different twist manipulation on whole-brain functional connectivity based on functional integration perspective.Methods:The 40 healthy subjects were randomly divided into the control group and the treatment group.The treatment group was further divided into the 120 r/min group,the 180 r/min group and the 240 r/min group according to different acupuncture manipulation,10 cases in each group.Each group was manipulated according to different stimulus parameters,but the control group only retained the needle without any manipulation.VAS was utilized to evaluate acupuncture sensation,and the difference of whole-brain functional connectivity was compared based on fMRI and ICA.Results:The VAS results showed that other sensations of acid,swelling,numbness and pain were significantly different in each group(P<0.01) except heaviness feeling.The ICA results revealed that after manipulation,the strength of wholebrain functional connectivity in the superior orbitofrontal gyrus was decreased in the 120 r/min group,the strength of wholebrain functional connectivity in the medial frontal gyrus was decreased in the 180 r/min group,and the strength of whole-brain functional connectivity in the middle temporal gyrus was increased in the 240 r/min group.There was no significantly change in the control group.Compared with the control group,the 120 r/min group showed that the strength of whole-brain functional connectivity in the calcarine was decreased,the 180 r/min group showed that the strength of whole-brain functional connectivity in the paracentral lobule was increased,and the 240 r/min group showed that the strength of whole-brain functional connectivity in the superior temporal gyrus,precuneus and superior frontal gyrus were decreased.Conclusion:Various twist manipulation have different responses on acupuncture sensation and whole-brain functional connectivity in subjects,which preliminarily predicts that different twist manipulation might produce different effects by mediat

关 键 词：捻转手法 全脑功能连接 独立成分分析 疗效预测 

分 类 号：R246[医药卫生—针灸推拿学]