Effect of drug therapies on self-reported chemosensory outcomes after COVID-19  

作　　者：Marco A.Fornazieri Bruno M.Cunha Samuel P.Nicácio Lucas K.Anzolin JoséL.B.da Silva Aristides Fernandes Neto Deusdedit Brandão Neto Richard L.Voegels Fábio D.R.Pinna 

机构地区：[1]Department of Surgery,Londrina State University,Londrina,Brazil [2]Department of Medicine,Pontifical Catholic University of Paraná,Londrina,Brazil [3]Department of Otorhinolaryngology,University of São Paulo,Sao Paulo,Brazil [4]Department of Otorhinolaryngology:Head and Neck Surgery,Perelman School of Medicine,Smell and Taste Center,University of Pennsylvania,Philadelphia,Pennsylvania,USA

出　　处：《World Journal of Otorhinolaryngology-Head and Neck Surgery》2024年第2期88-96,共9页世界耳鼻咽喉头颈外科杂志（英文）

摘　　要：Objective:The aim of this study was to assess the relative efficacy of medications used following severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection on self-reported alterations in taste and/or smell function.Methods:Seven hundred and fourteen persons with self-reported postcoronavirus disease 2019(post-COVID-19)chemosensory disorders were personally interviewed regarding specific medications they were administered following the acute phase of the disease.The dependent measure—self-reported total recovery of chemosensory symptoms—was subjected to stepwise logistic regression.Independent predictors included demographic and clinical variables,in addition to specific medications used to mitigate disease symptoms(i.e.,systemic corticosteroids,oseltamivir,vitamin C,ibuprofen,hydroxychloroquine,azithromycin,ivermectin,nitazoxanide,anticoagulants,and zinc).Results:The median time between COVID-19 symptom onset and the interviews was 81 days(interquartile range:60-104).Of the 714 subjects,249(34.9%)reported total recovery of their chemosensory function;437(61.2%)had at least one treatment since the beginning of the disease.Women and those with more comorbidities had undergone more treatments.The recovery rates of the treated and nontreated groups did not differ significantly.Nonetheless,respondents who had used nitazoxanide tended to have a higher rate of self-reported taste or smell recovery.Those who took oral zinc were less likely to improve.Conclusions:No medication employed during the first months after SARS-CoV-2 infection had a clear positive effect on returning self-reported smell or taste function to normal,although nitrazoxide trended in a positive direction.Oral zinc had a negative effect on the reported recovery of these senses.

关 键 词：chemosensory disorder coronavirus infections COVID-19 drug therapy SARS-CoV-2 smell loss taste loss 

分 类 号：R511[医药卫生—内科学]